GSE25544 Host/microbial cross-talk in the gut : in-depth investigation of the symbiotic effects of Roseburia hominis

  • Denise Kelly (Creator)
  • Guido Hooiveld (Creator)
  • Martijn Van Iersel (Creator)
  • Patrick D. Koks (Creator)
  • Ruan M Elliott (Creator)
  • Philippe Rocca-Serra (Creator)
  • Imke Elisabeth Mulder (Creator)
  • Peter John Morgan (Data Manager)



Here, we report analysis of both the bacterial and host transcriptome as affected by colonization of R. hominis in the mouse gut. Microbial genes required for colonization and adaptation in the murine gut, as well as host genes responding to colonization by this bacterial species, were uncovered.

Initial data analysis was performed using Affymetrix GCOS 1.2 software. Data were further analyzed using Bioconductor ( from the R Project for Statistical Computing ( Normalization was performed with gcRMA. The moderated t-test provided by the Bioconductor package limma was used to test for differential expression. Data was considered significant when P<0.05 using the Benjamini and Hochberg false discovery method.
Date made available5 Feb 2016
  • Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity

    Patterson, A. M., Mulder, I. E., Travis, A. J., Lan, A., Cerf-Bensussan, N., Gaboriau-Routhiau, V., Garden, K., Logan, E., Delday, M. I., Coutts, A. G. P., Monnais, E., Ferraria, V. C., Inoue, R., Grant, G. & Aminov, R. I., 26 Sept 2017, In: Frontiers in Immunology. 8, p. 1-14 14 p., 1166.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    100 Citations (Scopus)
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