Description of impact
Thalidomide was given to pregnant women around the world as a treatment for morning sickness in the 1960s, with the result that many miscarried or gave birth to malformed babies. It is still prescribed today for indications including multiple myeloma and complications of leprosy. The team at Aberdeen explored how – and crucially when – thalidomide disrupts limb formation and the range of other forms of damage caused by thalidomide. This research led to expert testimony in a landmark class action lawsuit in Australia in which 107 claimants were compensated over AUD100,000,000. Expert opinion based on the research has influenced international government policy to support thalidomide survivors and identification of hitherto unrecognised people damaged by thalidomide in Canada, Australia and Italy.Outcomes to Date / Future Developments
For decades, the legacy of the thalidomide tragedy has imposed upon the survivors and their families' lives filled with difficulty, pain and discrimination, in some cases without recognition or support. The Aberdeen research findings led to several impacts, including helping to identify and compensate thalidomide survivors, influencing international government responses by informing guidance for thalidomide embryopathy identification, and enhancing understanding of the effects of thalidomide.Impact status | Impact Completed (Open) |
---|---|
Impact date | 2008 → 2020 |
Keywords
- Health
Documents & Links
Related content
-
Research output
-
CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos
Research output: Contribution to journal › Article › peer-review
-
In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems
Research output: Contribution to journal › Article › peer-review
-
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation
Research output: Contribution to journal › Article › peer-review
-
A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica
Research output: Contribution to journal › Article › peer-review
-
Thalidomide upper limb embryopathy -: pathogenesis, past and present management and future considerations
Research output: Contribution to journal › Article › peer-review