Michael Simpson

2018

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A.-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. (Corresponding Author) & Serpell, L. C. (Corresponding Author), 19 Oct 2018, In: Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

33 Citations (Scopus)

21 Downloads (Pure)

2017

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 24 Nov 2017, In: Journal of Molecular Biology. 429, 23, p. 3650-3665 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

66 Citations (Scopus)

27 Downloads (Pure)

2015

Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease

Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J. & Wischik, C. M., 24 Apr 2015, In: The Journal of Biological Chemistry. 290, 17, p. 10862-10875 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

83 Citations (Scopus)

24 Downloads (Pure)

2012

New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

Baddeley, T. (Inventor), Clunas, S. (Inventor), Harrington, C. R. (Inventor), Horsley, D. (Inventor), Ishaq, A. (Inventor), Khan, K. (Inventor), Loh, Y. S. (Inventor), Marshall, C. (Inventor), Rickard, J. E. (Inventor), Simpson, M. (Inventor), Sinclair, J. P. (Inventor), Storey, J. M. D. (Inventor), Williamson, C. (Inventor), Wischik, C. M. (Inventor) & Wood, B. A. (Inventor), 16 Aug 2012, Patent No. WO2012107706-A1, Priority date 11 Feb 2011

Research output: Patent

2011

Development of ¹⁸F-fluorinatable dendrons and their application to cancer cell targeting

Trembleau, L., Simpson, M., Cheyne, R. W., Escofet, I., Appleyard, M. V. C. L., Murray, K., Sharp, S., Thompson, A. M. & Smith, T. A. D., Nov 2011, In: New Journal of Chemistry. 35, 11, p. 2496-2502 7 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

18F-PEG-biotin: Precursor (boroaryl-PEG-biotin) synthesis, 18F-labelling and an in-vitro assessment of its binding to NeutravidinTM -trastuzumab pre-treated cells

Smith, T. A. D., Simpson, M., Cheyne, R. W. & Trembleau, L. A. C., Oct 2011, In: Applied Radiation and Isotopes. 69, 10, p. 1395-1400 6 p.

Research output: Contribution to journal › Article › peer-review

File

10 Citations (Scopus)

11 Downloads (Pure)

One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor

Simpson, M., Trembleau, L. A. C., Cheyne, R. W. & Smith, T. A. D., Feb 2011, In: Applied Radiation and Isotopes. 69, 2, p. 418-422 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

12 Citations (Scopus)

12 Downloads (Pure)

2010

Materials and methods for medical imaging

Smith, T. A. D. (Inventor), Trembleau, L. A. C. (Inventor), McLaughlin, A. (Inventor) & Simpson, M. (Inventor), 2010, IPC No. WO2009056837, Patent No. GB2467494 (A)

Research output: Patent

2004

Diethyl 9,10-endo-ethano-9,10-dihydroanthracene-11,11-dicarboxylate

Simpson, M., Storey, J. M. D. & Harrison, W. T. A., 2004, In: Acta Crystallographica Section E: Structure Reports Online. E60, p. o1081-o1083 3 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

RbZrOAsO4: a zirconium-containing analogue of potassium titanyl phosphate (KTiOPO4)

Simpson, M. & Harrison, W. T. A., 2004, In: Solid State Sciences. 6, p. 981-985 5 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

2002

New Molecular Perovskites: Cubic C₄N₂H₁₂·NH₄Cl₃.H₂O and 2-H Hexagonal C₆N₂H₁₄·NH₄Cl₃

Bremner, C. A., Simpson, M. & Harrison, W. T. A., 2002, In: Journal of the American Chemical Society. 124, 37, p. 10960-10961 1 p.

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Michael Simpson

Research output

Search results