3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Mary E. Booth; Claire E. Nash; Nicholas P. Roberts; Derek R. Magee; Darren Treanor; Andrew M. Hanby; Valerie Speirs

3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Mary E. Booth
, Claire E. Nash
, Nicholas P. Roberts
, Derek R. Magee
, Darren Treanor
, Andrew M. Hanby
, Valerie Speirs^*

^*Corresponding author for this work

St James's University Hospital
McGill University
University of Leeds
Leeds Teaching Hospitals NHS Trust

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.

Original language	English
Pages (from-to)	377-383
Number of pages	7
Journal	ATLA Alternatives to Laboratory Animals
Volume	43
Issue number	6
Publication status	Published - 1 Dec 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

3-D
Cell culture
DCIS
Virtual pathology

Access to Document

http://www.atla.org.uk/booth43-6/Licence: Unspecified

Cite this

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title = "3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ",

abstract = "Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.",

keywords = "3-D, Cell culture, DCIS, Virtual pathology",

author = "Booth, \{Mary E.\} and Nash, \{Claire E.\} and Roberts, \{Nicholas P.\} and Magee, \{Derek R.\} and Darren Treanor and Hanby, \{Andrew M.\} and Valerie Speirs",

year = "2015",

month = dec,

day = "1",

language = "English",

volume = "43",

pages = "377--383",

journal = "ATLA Alternatives to Laboratory Animals",

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T1 - 3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

AU - Booth, Mary E.

AU - Nash, Claire E.

AU - Roberts, Nicholas P.

AU - Magee, Derek R.

AU - Treanor, Darren

AU - Hanby, Andrew M.

AU - Speirs, Valerie

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.

AB - Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.

KW - 3-D

KW - Cell culture

KW - DCIS

KW - Virtual pathology

UR - https://www.scopus.com/pages/publications/84956891387

M3 - Article

C2 - 26753940

AN - SCOPUS:84956891387

SN - 0261-1929

VL - 43

SP - 377

EP - 383

JO - ATLA Alternatives to Laboratory Animals

JF - ATLA Alternatives to Laboratory Animals

IS - 6

ER -

3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Abstract

UN SDGs

Keywords

Access to Document

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