Abstract
A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structure of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 538-541 |
| Number of pages | 4 |
| Journal | Journal of Natural Products |
| Volume | 61 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 25 May 1998 |
Funding
Financial support came from the Carnegie Trust and Nuffield Foundation. L.M. is the recipient of an EPSRC quota award (96309148), and E.M.C. was an undergraduate project student supported by Aberdeen University Chemistry Department. NMR data were obtained on the EPSRC Ultrahigh Field NMR Service Instrument at Edinburgh University. HRESIMS data was obtained at the Rowett Institute, Aberdeen, by Gary Duncan. M.J. participated in a University of California, Santa Cruz, marine natural products chemistry expedition partially supported by NIH Grant Nos. CA47135 and CA52955. Biological testing was performed at the Paterson Institute for Cancer Research at the Christie Hospital in Manchester by Sally Haran and Dee Evans, members of Alan McGown's research group.
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