A lifestyle intervention improves sexual function of women with obesity and infertility: A 5 year follow-up of a RCT

Vincent Wekker*, Matty D.A. Karsten, Rebecca C. Painter, Cornelieke Van De Beek, Henk Groen, Ben Willem J. Mol, Annemieke Hoek, Ellen Laan, Tessa J. Roseboom

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)
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Abstract

Background Obesity and infertility are associated with poorer sexual function. We have previously shown that a lifestyle intervention in women with obesity and infertility reduced weight and improved cardiometabolic health and quality of life, which may positively affect sexual function. We now report on sexual function 5 years after randomization. Methods and findings In total 577 women, between 18-39 years of age, with infertility and a BMI ?29 kg/m2 were randomized to a six-month lifestyle intervention targeting physical activity, diet and behavior modification or prompt infertility care as usual. Intercourse frequency and sexual function were assessed with the McCoy Female Sexuality Questionnaire (MFSQ), 5.4?0.8 years after randomization. 550 women could be approached for the follow-up study, of whom 84 women in the intervention and 93 in the control group completed the MFSQ. Results were adjusted for duration of infertility, polycystic ovary syndrome and whether women were attempting to conceive. The intervention group more often reported having had intercourse in the past 4 weeks compared to the control group (aOR: 2.3 95% CI 0.96 to 5.72). Among women reporting intercourse in the past 4 weeks, the intervention group (n = 75) had intercourse more frequently (6.6?5.8 vs. 4.9?4.0 times; 95% CI 0.10 to 3.40) and had higher scores for vaginal lubrication (16.5?3.0 vs. 15.4?3.5; 95% CI 0.15 to 2.32) and total 'sexual function' score (96.5?14.2 vs. 91.4?12.8; 95% CI 0.84 to 9.35) compared to the control group (n = 72). Sexual interest, satisfaction, orgasm and sex partner scores did not differstatistically between the groups. The intervention effect on sexual function was for 21% mediated by the change in moderate to vigorous physical activity. Conclusion A six-month lifestyle intervention in women with obesity and infertility led to more frequent intercourse, better vaginal lubrication and overall sexual function 5 years after the intervention. (Trial Registration: NTR1530).

Original languageEnglish
Article numbere0205934
Number of pages13
JournalPloS ONE
Volume13
Issue number10
DOIs
Publication statusPublished - 23 Oct 2018

Bibliographical note

Acknowledgments
We thank all the women who participated in this study. We thank all participating hospitals and their staff for their contribution to this study, and the lifestyle coaches, research nurses, research midwives and office members of the Dutch Consortium (www.studies-obsgyn.nl) for their hard work and dedication. Furthermore, we thank all members of the WOMB-project who contributed to the follow-up study; with special thanks to our colleague PhD students, post-docs, research assistants and students.

Data Availability Statement

All relevant data are within the paper and its Supporting Information files (S2 File: Minimal dataset).

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