A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes

J. K. Millar; J. Brown; J. C. Maule; Y. Shibasaki; S. Christie; D. Lawson; S. Anderson; J. C. Wilson-Annan; R. S. Devon; D. M. St Clair; D. H.R. Blackwood; W. J. Muir; D. J. Porteous

A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes

J. K. Millar^*, J. Brown, J. C. Maule, Y. Shibasaki, S. Christie, D. Lawson, S. Anderson, J. C. Wilson-Annan, R. S. Devon, D. M. St Clair, D. H.R. Blackwood, W. J. Muir, D. J. Porteous

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.

Original language	English
Pages (from-to)	175-181
Number of pages	7
Journal	Psychiatric Genetics
Volume	8
Issue number	3
Publication status	Published - 2 Nov 1998

Keywords

Gene identification
Long-range restriction map
Schizophrenia
Translocation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Millar, J. K., Brown, J., Maule, J. C., Shibasaki, Y., Christie, S., Lawson, D., Anderson, S., Wilson-Annan, J. C., Devon, R. S., St Clair, D. M., Blackwood, D. H. R., Muir, W. J., & Porteous, D. J. (1998). A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes. Psychiatric Genetics, 8(3), 175-181.

A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes. / Millar, J. K.; Brown, J.; Maule, J. C. et al.
In: Psychiatric Genetics, Vol. 8, No. 3, 02.11.1998, p. 175-181.

Research output: Contribution to journal › Article › peer-review

Millar, JK, Brown, J, Maule, JC, Shibasaki, Y, Christie, S, Lawson, D, Anderson, S, Wilson-Annan, JC, Devon, RS, St Clair, DM, Blackwood, DHR, Muir, WJ & Porteous, DJ 1998, 'A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes', Psychiatric Genetics, vol. 8, no. 3, pp. 175-181.

@article{2f9487195a6541988bd4be387ad4d895,

title = "A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes",

abstract = "A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.",

keywords = "Gene identification, Long-range restriction map, Schizophrenia, Translocation",

author = "Millar, {J. K.} and J. Brown and Maule, {J. C.} and Y. Shibasaki and S. Christie and D. Lawson and S. Anderson and Wilson-Annan, {J. C.} and Devon, {R. S.} and {St Clair}, {D. M.} and Blackwood, {D. H.R.} and Muir, {W. J.} and Porteous, {D. J.}",

year = "1998",

month = nov,

day = "2",

language = "English",

volume = "8",

pages = "175--181",

journal = "Psychiatric Genetics",

issn = "0955-8829",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia

T2 - Localization of the breakpoint and the search for neighbouring genes

AU - Millar, J. K.

AU - Brown, J.

AU - Maule, J. C.

AU - Shibasaki, Y.

AU - Christie, S.

AU - Lawson, D.

AU - Anderson, S.

AU - Wilson-Annan, J. C.

AU - Devon, R. S.

AU - St Clair, D. M.

AU - Blackwood, D. H.R.

AU - Muir, W. J.

AU - Porteous, D. J.

PY - 1998/11/2

Y1 - 1998/11/2

N2 - A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.

AB - A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.

KW - Gene identification

KW - Long-range restriction map

KW - Schizophrenia

KW - Translocation

UR - http://www.scopus.com/inward/record.url?scp=15144357926&partnerID=8YFLogxK

M3 - Article

C2 - 9800219

AN - SCOPUS:15144357926

SN - 0955-8829

VL - 8

SP - 175

EP - 181

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 3

ER -

A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes

Abstract

Keywords

UN SDGs

Other files and links

Fingerprint

Cite this