A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Nathaniel Rothman, Montserrat Garcia-Closas*, Nilanjan Chatterjee, Nuria Malats, Xifeng Wu, Jonine D. Figueroa, Francisco X. Real, David Van Den Berg, Giuseppe Matullo, Dalsu Baris, Michael Thun, Lambertus A. Kiemeney, Paolo Vineis, Immaculata De Vivo, Demetrius Albanes, Mark P. Purdue, Thorunn Rafnar, Michelle A.T. Hildebrandt, Anne E. Kiltie, Olivier CussenotKlaus Golka, Rajiv Kumar, Jack A. Taylor, Jose I. Mayordomo, Kevin B. Jacobs, Manolis Kogevinas, Amy Hutchinson, Zhaoming Wang, Yi Ping Fu, Ludmila Prokunina-Oolsson, Laurie BurdeT, Meredith Yeager, William Wheeler, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Cclosas, Josep Loreta, Alison Johnson, Molly Schwenn, Margaret R. Karagas, Alan Schned, Gerald Andriole, Robert Grubb, Amanda Black, Eric J. Jacobs, W. Ryan Diver, Susan M. Gapstur, Stephanie J. Weinstein, Jarmo Virtamo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

350 Citations (Scopus)


We conducted a multi-stage, genome-wide aSociation study of blaDer cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies foLowed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified thrE new regions aSociated with blaDer cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8-10-12) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2-10-11) on 19q12 maps to CNE1 and rs11892031 (P = 1-10-7) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide aSociations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate aSociations for the GSTM1 deletion (P = 4-10-11) and a tag SNP for NAT2 acetylation status (P = 4-10-11), and found interactions with smoking in both regions. Our findings on coMon variants aSociated with blaDer cancer risk should provide new insights into the mechanisms of carcinogenesis.

Original languageEnglish
Pages (from-to)978-984
Number of pages7
JournalNature Genetics
Issue number11
Publication statusPublished - 1 Nov 2010

Bibliographical note

Funding Information:
The bladder cancer GWAS was supported by the intramural research program of the US National Institutes of Health, National Cancer Institute.

This project has been funded in part with federal funds from the National Cancer Institute, US National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. Please see Supplementary Note for information on support for individual studies that participated in the effort.


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