A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

Xiaodong Zeng; Ziyang Chen; Lin Tang; Han Yang; Nan Liu; Hui Zhou; Yang Li; Junzhu Wu; Zixin Deng; Yi  Yu; Hai Deng; Xuechuan Hong; Yuling Xiao

doi:10.1039/c8cc10286d

A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

Xiaodong Zeng
, Ziyang Chen
, Lin Tang
, Han Yang
, Nan Liu
, Hui Zhou
, Yang Li
, Junzhu Wu
, Zixin Deng
, Yi Yu
, Hai Deng^* (Corresponding Author)
, Xuechuan Hong^* (Corresponding Author)
, Yuling Xiao^* (Corresponding Author)

^*Corresponding author for this work

Wuhan University
Center for Experimental Basic Medical Education

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.

Original language	English
Pages (from-to)	2541-2544
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	17
Early online date	30 Jan 2019
DOIs	https://doi.org/10.1039/c8cc10286d
Publication status	Published - 28 Feb 2019

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10.1039/c8cc10286dLicence: Unspecified

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abstract = "A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.",

author = "Xiaodong Zeng and Ziyang Chen and Lin Tang and Han Yang and Nan Liu and Hui Zhou and Yang Li and Junzhu Wu and Zixin Deng and Yi Yu and Hai Deng and Xuechuan Hong and Yuling Xiao",

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T1 - A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

AU - Zeng, Xiaodong

AU - Chen, Ziyang

AU - Tang, Lin

AU - Yang, Han

AU - Liu, Nan

AU - Zhou, Hui

AU - Li, Yang

AU - Wu, Junzhu

AU - Deng, Zixin

AU - Yu, Yi

AU - Deng, Hai

AU - Hong, Xuechuan

AU - Xiao, Yuling

PY - 2019/2/28

Y1 - 2019/2/28

N2 - A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.

AB - A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.

UR - http://www.mendeley.com/research/novel-nearinfrared-fluorescent-lightup-probe-tumor-imaging-druginduced-liver-injury-detection

U2 - 10.1039/c8cc10286d

DO - 10.1039/c8cc10286d

M3 - Article

C2 - 30742156

SN - 1359-7345

VL - 55

SP - 2541

EP - 2544

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

Abstract

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