A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis

Tiara Ratz, Linda E Dean, Fabiola Atzeni, Christopher Reeks, Gary J Macfarlane, Tatiana MacFarlane

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
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OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.

METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.

RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38% to 88% in AS patients and from 26% to 71% in controls. As there was low-level heterogeneity (I(2) = 13%), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95% CI 1.72, 1.98). There was no evidence of publication bias.

CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.

Original languageEnglish
Pages (from-to)500-510
Number of pages11
Issue number3
Early online date10 Sept 2014
Publication statusPublished - Mar 2015

Bibliographical note

© The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

We are grateful to Melanie Bickerton, from the Medical Library University of Aberdeen, and Dr Simon Stebbings Professor W. Murray Thompson and Associate Professor Mary P. Cullinan for providing additional information about their studies. T.R. worked on the project while taking part in an Erasmus student placement under the European Lifelong Learning Programme. L.D. received funding from the Medical Research Council to undertake her PhD.
Disclosure statement: The authors have declared no conflicts of interest.


  • ankylosing spondylitis
  • periodontitis
  • epidemiology
  • prevalence
  • dental


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