A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines

Andrea Bilger; L Michelle Bennett; Reynaldo A Carabeo; Teresa A Chiaverotti; Cecily Dvorak; Kristin M Liss; Susan A Schadewald; Henry C Pitot; Norman R Drinkwater

doi:10.1534/genetics.103.024521

A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines

Andrea Bilger, L Michelle Bennett, Reynaldo A Carabeo, Teresa A Chiaverotti, Cecily Dvorak, Kristin M Liss, Susan A Schadewald, Henry C Pitot, Norman R Drinkwater

Medical Sciences

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Abstract

The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LOD(W) scores of approximately 5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P <10(-11), in males; 3- to 4-fold, P <10(-3), in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.

Original language	English
Pages (from-to)	859-66
Number of pages	8
Journal	Genetics
Volume	167
Issue number	2
DOIs	https://doi.org/10.1534/genetics.103.024521
Publication status	Published - Jun 2004

Keywords

Liver Neoplasms
Risk
Animals
Rodent Diseases
Mice
Species Specificity
Chromosome Mapping

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1534/genetics.103.024521

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title = "A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines",

abstract = "The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LOD(W) scores of approximately 5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P <10(-11), in males; 3- to 4-fold, P <10(-3), in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.",

keywords = "Liver Neoplasms, Risk, Animals, Rodent Diseases, Mice, Species Specificity, Chromosome Mapping",

author = "Andrea Bilger and Bennett, {L Michelle} and Carabeo, {Reynaldo A} and Chiaverotti, {Teresa A} and Cecily Dvorak and Liss, {Kristin M} and Schadewald, {Susan A} and Pitot, {Henry C} and Drinkwater, {Norman R}",

year = "2004",

month = jun,

doi = "10.1534/genetics.103.024521",

language = "English",

volume = "167",

pages = "859--66",

journal = "Genetics",

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publisher = "Genetics Society of America",

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T1 - A potent modifier of liver cancer risk on distal mouse chromosome 1

T2 - linkage analysis and characterization of congenic lines

AU - Bilger, Andrea

AU - Bennett, L Michelle

AU - Carabeo, Reynaldo A

AU - Chiaverotti, Teresa A

AU - Dvorak, Cecily

AU - Liss, Kristin M

AU - Schadewald, Susan A

AU - Pitot, Henry C

AU - Drinkwater, Norman R

PY - 2004/6

Y1 - 2004/6

N2 - The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LOD(W) scores of approximately 5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P <10(-11), in males; 3- to 4-fold, P <10(-3), in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.

AB - The C3H/HeJ (C3H) and CBA/J (CBA) mouse strains are classical mouse models of cancer susceptibility, exhibiting high risks for both spontaneous and chemically induced liver cancer. By analysis of backcrosses and intercrosses between C3H or CBA and resistant B6 mice, we have mapped a potent modifier of hepatocellular carcinoma development to distal chromosome 1, linked to the marker D1Mit33 with combined LOD(W) scores of approximately 5.9 (C3H) and 6.5 (CBA). We previously identified this region as one of two that modify susceptibility in the more distantly related C57BR/cdJ (BR) strain. Congenic B6.C3H(D1Mit5-D1Mit17) and B6.BR(D1Mit5-D1Mit17) mice developed significantly more liver tumors than B6 mice did (6- to 13-fold, P <10(-11), in males; 3- to 4-fold, P <10(-3), in females). Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer.

KW - Liver Neoplasms

KW - Risk

KW - Animals

KW - Rodent Diseases

KW - Mice

KW - Species Specificity

KW - Chromosome Mapping

U2 - 10.1534/genetics.103.024521

DO - 10.1534/genetics.103.024521

M3 - Article

C2 - 15238534

SN - 0016-6731

VL - 167

SP - 859

EP - 866

JO - Genetics

JF - Genetics

IS - 2

ER -

A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines

Abstract

Keywords

UN SDGs

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