An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

Anthony R Butler; Robert A. Field; Iain Robert Greig; Frederick W Flitney; Stuart K Bisland; Faisal Khan; Jill J F Belch

doi:10.1006/niox.1997.0125

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

Anthony R Butler
, Robert A. Field
, Iain Robert Greig
, Frederick W Flitney
, Stuart K Bisland
, Faisal Khan
, Jill J F Belch

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	Nitric Oxide: Biology and Chemistry
Volume	1
Issue number	3
DOIs	https://doi.org/10.1006/niox.1997.0125
Publication status	Published - Jun 1997
Externally published	Yes

Bibliographical note

Acknowledgements
The scanning Doppler laser imager was purchased with a grant from Tenovus. The Arthritis & Rheumatism Council and the Rollo Trust contributed to the cost of consumables

Access to Document

10.1006/niox.1997.0125

Cite this

@article{3d6faf5d8594481697f21aabdf9206cf,

title = "An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.",

abstract = "A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.",

author = "Butler, \{Anthony R\} and Field, \{Robert A.\} and Greig, \{Iain Robert\} and Flitney, \{Frederick W\} and Bisland, \{Stuart K\} and Faisal Khan and Belch, \{Jill J F\}",

note = "Acknowledgements The scanning Doppler laser imager was purchased with a grant from Tenovus. The Arthritis \& Rheumatism Council and the Rollo Trust contributed to the cost of consumables",

year = "1997",

month = jun,

doi = "10.1006/niox.1997.0125",

language = "English",

volume = "1",

pages = "211--217",

journal = "Nitric Oxide: Biology and Chemistry",

issn = "1089-8603",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

AU - Butler, Anthony R

AU - Field, Robert A.

AU - Greig, Iain Robert

AU - Flitney, Frederick W

AU - Bisland, Stuart K

AU - Khan, Faisal

AU - Belch, Jill J F

N1 - Acknowledgements The scanning Doppler laser imager was purchased with a grant from Tenovus. The Arthritis & Rheumatism Council and the Rollo Trust contributed to the cost of consumables

PY - 1997/6

Y1 - 1997/6

N2 - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

AB - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

UR - https://doi.org/10.1006/niox.1997.0125

U2 - 10.1006/niox.1997.0125

DO - 10.1006/niox.1997.0125

M3 - Article

C2 - 9704582

SN - 1089-8603

VL - 1

SP - 211

EP - 217

JO - Nitric Oxide: Biology and Chemistry

JF - Nitric Oxide: Biology and Chemistry

IS - 3

ER -

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this