Apolipoprotein E gene variability and cognitive functioning at age 79: follow-up of the Scottish Mental survey 1932

I. J. Deary; M. C. Whiteman; A. Pattie; J. M. Starr; C. Hayward; A. F. Wright; P. Visscher; Lawrence Jeffrey Whalley

doi:10.1037/0882-7974.19.2.367

Apolipoprotein E gene variability and cognitive functioning at age 79: follow-up of the Scottish Mental survey 1932

I. J. Deary, M. C. Whiteman, A. Pattie, J. M. Starr, C. Hayward, A. F. Wright, P. Visscher, Lawrence Jeffrey Whalley

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Apolipoprotein E (APOE) genotype is a possible influence on nonpathological cognitive aging. The authors studied 462 community-dwelling, 79-year-old people born in 1921, whose childhood IQ had been assessed in the Scottish Mental Survey of 1932 (Scottish Council for Research in Education, 1933). Adjusting for sex, childhood IQ, and self-reported illnesses, the authors found that those with an APOE epsilon4 allele had significantly lower Wechsler Logical Memory (D. Wechsler, 1987) scores than those without an epsilon4 allele. Those people with APOE epsilon2/epsilon3 genotypes had significantly higher Wechsler Logical Memory scores than epsilon3/epsilon3, who were significantly higher than epsilon3/epsilon4. Neither nonverbal reasoning nor verbal fluency were affected. In this sample, APOE genotype contributed to verbal memory in old age.

Original language	English
Pages (from-to)	367-371
Number of pages	4
Journal	Psychology and Aging
Volume	19
DOIs	https://doi.org/10.1037/0882-7974.19.2.367
Publication status	Published - 2004

Keywords

EPSILON-4 ALLELE
OLD-AGE
INDIVIDUAL-DIFFERENCES
MEMORY PERFORMANCE
ALZHEIMERS-DISEASE
COMMUNITY SAMPLE
E POLYMORPHISM
APOE GENOTYPE
DECLINE
APOE-EPSILON-4

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title = "Apolipoprotein E gene variability and cognitive functioning at age 79: follow-up of the Scottish Mental survey 1932",

abstract = "Apolipoprotein E (APOE) genotype is a possible influence on nonpathological cognitive aging. The authors studied 462 community-dwelling, 79-year-old people born in 1921, whose childhood IQ had been assessed in the Scottish Mental Survey of 1932 (Scottish Council for Research in Education, 1933). Adjusting for sex, childhood IQ, and self-reported illnesses, the authors found that those with an APOE epsilon4 allele had significantly lower Wechsler Logical Memory (D. Wechsler, 1987) scores than those without an epsilon4 allele. Those people with APOE epsilon2/epsilon3 genotypes had significantly higher Wechsler Logical Memory scores than epsilon3/epsilon3, who were significantly higher than epsilon3/epsilon4. Neither nonverbal reasoning nor verbal fluency were affected. In this sample, APOE genotype contributed to verbal memory in old age.",

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author = "Deary, {I. J.} and Whiteman, {M. C.} and A. Pattie and Starr, {J. M.} and C. Hayward and Wright, {A. F.} and P. Visscher and Whalley, {Lawrence Jeffrey}",

year = "2004",

doi = "10.1037/0882-7974.19.2.367",

language = "English",

volume = "19",

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T1 - Apolipoprotein E gene variability and cognitive functioning at age 79: follow-up of the Scottish Mental survey 1932

AU - Deary, I. J.

AU - Whiteman, M. C.

AU - Pattie, A.

AU - Starr, J. M.

AU - Hayward, C.

AU - Wright, A. F.

AU - Visscher, P.

AU - Whalley, Lawrence Jeffrey

PY - 2004

Y1 - 2004

N2 - Apolipoprotein E (APOE) genotype is a possible influence on nonpathological cognitive aging. The authors studied 462 community-dwelling, 79-year-old people born in 1921, whose childhood IQ had been assessed in the Scottish Mental Survey of 1932 (Scottish Council for Research in Education, 1933). Adjusting for sex, childhood IQ, and self-reported illnesses, the authors found that those with an APOE epsilon4 allele had significantly lower Wechsler Logical Memory (D. Wechsler, 1987) scores than those without an epsilon4 allele. Those people with APOE epsilon2/epsilon3 genotypes had significantly higher Wechsler Logical Memory scores than epsilon3/epsilon3, who were significantly higher than epsilon3/epsilon4. Neither nonverbal reasoning nor verbal fluency were affected. In this sample, APOE genotype contributed to verbal memory in old age.

AB - Apolipoprotein E (APOE) genotype is a possible influence on nonpathological cognitive aging. The authors studied 462 community-dwelling, 79-year-old people born in 1921, whose childhood IQ had been assessed in the Scottish Mental Survey of 1932 (Scottish Council for Research in Education, 1933). Adjusting for sex, childhood IQ, and self-reported illnesses, the authors found that those with an APOE epsilon4 allele had significantly lower Wechsler Logical Memory (D. Wechsler, 1987) scores than those without an epsilon4 allele. Those people with APOE epsilon2/epsilon3 genotypes had significantly higher Wechsler Logical Memory scores than epsilon3/epsilon3, who were significantly higher than epsilon3/epsilon4. Neither nonverbal reasoning nor verbal fluency were affected. In this sample, APOE genotype contributed to verbal memory in old age.

KW - EPSILON-4 ALLELE

KW - OLD-AGE

KW - INDIVIDUAL-DIFFERENCES

KW - MEMORY PERFORMANCE

KW - ALZHEIMERS-DISEASE

KW - COMMUNITY SAMPLE

KW - E POLYMORPHISM

KW - APOE GENOTYPE

KW - DECLINE

KW - APOE-EPSILON-4

U2 - 10.1037/0882-7974.19.2.367

DO - 10.1037/0882-7974.19.2.367

M3 - Article

SN - 0882-7974

VL - 19

SP - 367

EP - 371

JO - Psychology and Aging

JF - Psychology and Aging

ER -

Apolipoprotein E gene variability and cognitive functioning at age 79: follow-up of the Scottish Mental survey 1932

Abstract

Keywords

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