Aspirin, salicylates, and cancer

Peter C. Elwood, Alison M. Gallagher, Garry G. Duthie, Luis A. J. Mur, Gareth Morgan

Research output: Contribution to journalArticlepeer-review

253 Citations (Scopus)


Evidence from a wide range of sources suggests that individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of large bowel cancer. Work in animals supports cancer reduction with aspirin, but no long-term randomised clinical trials exist in human beings, and randomisation would be ethically unacceptable because vascular protection would have to be denied to a proportion of the participants. However, opportunistic trials of aspirin, designed to test vascular protection, provide some evidence of a reduction in cancer, but only after at least 10 years. We summarise evidence for the potential benefit of aspirin and natural salicylates in cancer prevention. Possible mechanisms of action and directions for further work are discussed, and implications for clinical practice are considered.

Original languageEnglish
Pages (from-to)1301-1309
Number of pages9
JournalThe Lancet
Issue number9671
Early online date26 Mar 2009
Publication statusPublished - 11 Apr 2009


  • nonsteroidal antiinflammatory drugs
  • low-dose aspirin
  • randomized controlled-trials
  • prevent colorectal adenomas
  • breast-cancer
  • colon-cancer
  • mediated apoptosis
  • sodium-salicycate
  • induced apoptosis
  • genomic instability


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