Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Maryam Mardan-Nik; Alireza Pasdar; Khadijeh Jamialahmadi; Amir Avan; Mohsen Mohebati; Habibollah Esmaily; Atefeh Biabangard-Zak; Fahimeh Afzal Javan; Mahdi Rivandi; Gordon A. Ferns; Majid Ghayour-Mobarhan

doi:10.3109/03014460.2015.1119309

Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Maryam Mardan-Nik
, Alireza Pasdar
, Khadijeh Jamialahmadi
, Amir Avan
, Mohsen Mohebati
, Habibollah Esmaily
, Atefeh Biabangard-Zak
, Fahimeh Afzal Javan
, Mahdi Rivandi
, Gordon A. Ferns
, Majid Ghayour-Mobarhan^*

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

6 Downloads (Pure)

Abstract

Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.

Original language	English
Pages (from-to)	542-546
Number of pages	5
Journal	Annals of Human Biology
Volume	43
Issue number	6
Early online date	10 Feb 2016
DOIs	https://doi.org/10.3109/03014460.2015.1119309
Publication status	Published - 1 Nov 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

coronary artery disease
heat shock protein 70
Obesity
PCR-RFLP
polymorphism

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Mardan_nik_etal_Association_heat_shock_VOR
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Cite this

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title = "Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity",

abstract = "Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.",

keywords = "coronary artery disease, heat shock protein 70, Obesity, PCR-RFLP, polymorphism",

author = "Maryam Mardan-Nik and Alireza Pasdar and Khadijeh Jamialahmadi and Amir Avan and Mohsen Mohebati and Habibollah Esmaily and Atefeh Biabangard-Zak and \{Afzal Javan\}, Fahimeh and Mahdi Rivandi and Ferns, \{Gordon A.\} and Majid Ghayour-Mobarhan",

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AU - Mardan-Nik, Maryam

AU - Pasdar, Alireza

AU - Jamialahmadi, Khadijeh

AU - Avan, Amir

AU - Mohebati, Mohsen

AU - Esmaily, Habibollah

AU - Biabangard-Zak, Atefeh

AU - Afzal Javan, Fahimeh

AU - Rivandi, Mahdi

AU - Ferns, Gordon A.

AU - Ghayour-Mobarhan, Majid

PY - 2016/11/1

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N2 - Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.

AB - Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.

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KW - heat shock protein 70

KW - Obesity

KW - PCR-RFLP

KW - polymorphism

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Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Abstract

UN SDGs

Keywords

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