Association of high level of hs-CRP with in-stent restenosis: A case-control study

Mojtaba Baktashian, Sara Saffar Soflaei, Negin Kosari, Mansoor Salehi, Alireza Khosravi, Maliheh Ahmadinejad, Mohsen Moohebati, Mahmood Ebrahimi, Farzad Rahmani, Ramin Khameneh-Bagheri, Mostafa Ahmadi, Fatemeh Sadabadi, Maryam Tayefi, Suzan Bazhdanzadeh, Gordon A. Ferns, Seyed Mohammad Hashemi*, Alireza Pasdar, Majid Ghayour-Mobarhan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Background: In-stent restenosis (ISR) is one adverse outcome of coronary stent implantation. Although using drug-eluting stents has reduced the rate of ISR, it remains a major problem. Here, we have investigated the relationship between several patient characteristics including serum high sensitive C-reactive protein (hs-CRP) and ISR. Methods: This was a case-control study comprising 104 individuals with ISR and 202 patients without. Baseline characteristics were collected using a questionnaire. Fasting blood glucose (FBG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and serum high sensitivity C-reactive protein (hs-CRP) were measured using commercial kits on an auto-analyzer. Data were analyzed using SPSS software and a p value ≤ 0.05 was considered significant. Results: Diabetes mellitus (p < 0.001), stent type (p = 0.005), serum hs-CRP (p = 0.006), FBG (p = 0.038) and serum TG (p = 0.039) were significantly associated with ISR. The association between hs-CRP and ISR remained significant after adjustment for stent type and DM. For patients with a serum hs-CRP <2.64 mg/dL, ISR was only associated with diabetes mellitus (p = 0.016); while for individuals with a serum hs-CRP ≥2.64 mg/dL, ISR was also associated with the presence of diabetes mellitus, serum triglycerides and stent type. Conclusion: Higher levels of serum hs-CRP were significantly associated with the occurrence of ISR.

Original languageEnglish
Pages (from-to)583-587
Number of pages5
JournalCardiovascular Revascularization Medicine
Issue number7
Early online date18 Aug 2018
Publication statusPublished - Jul 2019

Bibliographical note

The study protocol was given approval by the Ethics Committee of Mashhad University of Medical Sciences and written informed consent was obtained from participants.

Funding Information:
This study was supported by Mashhad University of Medical Sciences . The authors would like to thank technicians of Sina, Sadi, Ghaem catheterization laboratory and technicians of Isfahan Alzahra genetics laboratory.

Publisher Copyright:
© 2018 Elsevier Inc.


  • Bare stent
  • Drug-eluting stent
  • Hs-CRP
  • In-stent restenosis (ISR)


Dive into the research topics of 'Association of high level of hs-CRP with in-stent restenosis: A case-control study'. Together they form a unique fingerprint.

Cite this