Autoimmune Conditions and Gastric Cancer Risk in a Population-based Study in the United Kingdom

John D.  Murphy; Shahinaz M. Gadalla; Lesley Anderson; Charles S Rabkin; Chris R Cardwell; Minkyo  Song; M. Constanza Camargo

doi:10.1038/s41416-024-02714-7

Autoimmune Conditions and Gastric Cancer Risk in a Population-based Study in the United Kingdom

John D. Murphy, Shahinaz M. Gadalla, Lesley Anderson, Charles S Rabkin, Chris R Cardwell, Minkyo Song, M. Constanza Camargo^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Downloads (Pure)

Abstract

Background: Although overall incidence of gastric cancer is decreasing, incidence has been
increasing among young people in some Western countries. This trend may stem from the
increase in autoimmune conditions.
Methods: Nested case-control study of gastric cancer in UK Clinical Practice Research Datalink. Up to ten cancer-free controls were matched to cases by age and sex. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between analyzable autoimmune conditions (n=34) and gastric cancer with
Bonferroni correction. We evaluated associations between pernicious anaemia and other
conditions. A meta-analysis of published prospective studies and ours was conducted.
Results: Among 6,586 cases (1,156 cardia, 1,104 non-cardia, and 4,334 overlapping/unspecified
tumours) and 65,687 controls, any autoimmune condition was associated with gastric cancer
(OR=1.10; 95% CI: 1.01–1.20). Individuals with pernicious anaemia had higher gastric cancer
risk than those without (OR=2.75; 2.19-3.44). Among controls, pernicious anaemia was
associated with seven other conditions (OR range: 2.21-29.80). The pooled estimate for any
autoimmune condition and gastric cancer was 1.17 (1.14–1.21; n=47,126 cases).
Conclusion: Autoimmunity increases gastric cancer risk. Some autoimmune conditions may be indirectly associated with gastric cancer via pernicious anaemia. Pernicious anaemia could be considered for gastric cancer risk stratification and screening.

Original language	English
Pages (from-to)	138-148
Number of pages	11
Journal	British Journal of Cancer
Volume	131
Early online date	22 May 2024
DOIs	https://doi.org/10.1038/s41416-024-02714-7
Publication status	Published - 27 Jul 2024

Bibliographical note

ACKNOWLEDGMENTS
This study is based in part on data from the Clinical Practice Research Datalink obtained under
license from the UK Medicines and Healthcare Products Regulatory Agency. However, the
interpretation and conclusions contained in this study are those of the authors alone. The authors wish to thank Emily Carver and Michael Curry of IMS, Inc. for their assistance with accessing the data for this study

Data Availability Statement

Access to data from CPRD is subject to a full license agreement containing detailed terms and conditions of use. Anonymised patient datasets can be extracted for researchers against specific study specifications, following protocol approval via CPRD's Research Data Governance Process (https://cprd.com/data-access).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41416-024-02714-7Licence: CC BY

Murphy_etal_BJC_Autoimmune_conditions_gastric_VOR
https://creativecommons.org/licenses/by/4.0/
Final published version, 493 KBLicence: CC BY

Cite this

@article{a5817a254ee24f4092f22a18c040be65,

title = "Autoimmune Conditions and Gastric Cancer Risk in a Population-based Study in the United Kingdom",

abstract = "Background: Although overall incidence of gastric cancer is decreasing, incidence has beenincreasing among young people in some Western countries. This trend may stem from theincrease in autoimmune conditions.Methods: Nested case-control study of gastric cancer in UK Clinical Practice Research Datalink. Up to ten cancer-free controls were matched to cases by age and sex. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between analyzable autoimmune conditions (n=34) and gastric cancer withBonferroni correction. We evaluated associations between pernicious anaemia and otherconditions. A meta-analysis of published prospective studies and ours was conducted.Results: Among 6,586 cases (1,156 cardia, 1,104 non-cardia, and 4,334 overlapping/unspecifiedtumours) and 65,687 controls, any autoimmune condition was associated with gastric cancer(OR=1.10; 95% CI: 1.01–1.20). Individuals with pernicious anaemia had higher gastric cancerrisk than those without (OR=2.75; 2.19-3.44). Among controls, pernicious anaemia wasassociated with seven other conditions (OR range: 2.21-29.80). The pooled estimate for anyautoimmune condition and gastric cancer was 1.17 (1.14–1.21; n=47,126 cases).Conclusion: Autoimmunity increases gastric cancer risk. Some autoimmune conditions may be indirectly associated with gastric cancer via pernicious anaemia. Pernicious anaemia could be considered for gastric cancer risk stratification and screening. ",

author = "Murphy, {John D.} and Gadalla, {Shahinaz M.} and Lesley Anderson and Rabkin, {Charles S} and Cardwell, {Chris R} and Minkyo Song and Camargo, {M. Constanza}",

note = "ACKNOWLEDGMENTS This study is based in part on data from the Clinical Practice Research Datalink obtained under license from the UK Medicines and Healthcare Products Regulatory Agency. However, the interpretation and conclusions contained in this study are those of the authors alone. The authors wish to thank Emily Carver and Michael Curry of IMS, Inc. for their assistance with accessing the data for this study",

year = "2024",

month = jul,

day = "27",

doi = "10.1038/s41416-024-02714-7",

language = "English",

volume = "131",

pages = "138--148",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Autoimmune Conditions and Gastric Cancer Risk in a Population-based Study in the United Kingdom

AU - Murphy, John D.

AU - Gadalla, Shahinaz M.

AU - Anderson, Lesley

AU - Rabkin, Charles S

AU - Cardwell, Chris R

AU - Song, Minkyo

AU - Camargo, M. Constanza

N1 - ACKNOWLEDGMENTS This study is based in part on data from the Clinical Practice Research Datalink obtained under license from the UK Medicines and Healthcare Products Regulatory Agency. However, the interpretation and conclusions contained in this study are those of the authors alone. The authors wish to thank Emily Carver and Michael Curry of IMS, Inc. for their assistance with accessing the data for this study

PY - 2024/7/27

Y1 - 2024/7/27

N2 - Background: Although overall incidence of gastric cancer is decreasing, incidence has beenincreasing among young people in some Western countries. This trend may stem from theincrease in autoimmune conditions.Methods: Nested case-control study of gastric cancer in UK Clinical Practice Research Datalink. Up to ten cancer-free controls were matched to cases by age and sex. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between analyzable autoimmune conditions (n=34) and gastric cancer withBonferroni correction. We evaluated associations between pernicious anaemia and otherconditions. A meta-analysis of published prospective studies and ours was conducted.Results: Among 6,586 cases (1,156 cardia, 1,104 non-cardia, and 4,334 overlapping/unspecifiedtumours) and 65,687 controls, any autoimmune condition was associated with gastric cancer(OR=1.10; 95% CI: 1.01–1.20). Individuals with pernicious anaemia had higher gastric cancerrisk than those without (OR=2.75; 2.19-3.44). Among controls, pernicious anaemia wasassociated with seven other conditions (OR range: 2.21-29.80). The pooled estimate for anyautoimmune condition and gastric cancer was 1.17 (1.14–1.21; n=47,126 cases).Conclusion: Autoimmunity increases gastric cancer risk. Some autoimmune conditions may be indirectly associated with gastric cancer via pernicious anaemia. Pernicious anaemia could be considered for gastric cancer risk stratification and screening.

AB - Background: Although overall incidence of gastric cancer is decreasing, incidence has beenincreasing among young people in some Western countries. This trend may stem from theincrease in autoimmune conditions.Methods: Nested case-control study of gastric cancer in UK Clinical Practice Research Datalink. Up to ten cancer-free controls were matched to cases by age and sex. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between analyzable autoimmune conditions (n=34) and gastric cancer withBonferroni correction. We evaluated associations between pernicious anaemia and otherconditions. A meta-analysis of published prospective studies and ours was conducted.Results: Among 6,586 cases (1,156 cardia, 1,104 non-cardia, and 4,334 overlapping/unspecifiedtumours) and 65,687 controls, any autoimmune condition was associated with gastric cancer(OR=1.10; 95% CI: 1.01–1.20). Individuals with pernicious anaemia had higher gastric cancerrisk than those without (OR=2.75; 2.19-3.44). Among controls, pernicious anaemia wasassociated with seven other conditions (OR range: 2.21-29.80). The pooled estimate for anyautoimmune condition and gastric cancer was 1.17 (1.14–1.21; n=47,126 cases).Conclusion: Autoimmunity increases gastric cancer risk. Some autoimmune conditions may be indirectly associated with gastric cancer via pernicious anaemia. Pernicious anaemia could be considered for gastric cancer risk stratification and screening.

U2 - 10.1038/s41416-024-02714-7

DO - 10.1038/s41416-024-02714-7

M3 - Article

C2 - 38778220

SN - 0007-0920

VL - 131

SP - 138

EP - 148

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Autoimmune Conditions and Gastric Cancer Risk in a Population-based Study in the United Kingdom

Abstract

Bibliographical note

Data Availability Statement

UN SDGs

Access to Document

Fingerprint

Cite this