Behavioural optimisation to address trial conduct challenges: case study in the UK-REBOA trial

Louisa Lawrie* (Corresponding Author), Eilidh M. Duncan, Jan O. Jansen, Marion K. Campbell, Dan Brunsdon, Zoë Skea, Taylor Coffey, Claire Cochran, Katie Gillies

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
4 Downloads (Pure)


Clinical trials comprise multiple processes at various stages of the trial lifecycle. These processes often involve complex behaviours such as recruiting vulnerable patient populations and clinicians having to deliver complex trial interventions successfully. Few studies have utilised a behavioural framework to assess challenges and develop strategies for effective trial recruitment and delivery of trial interventions. This study reports the application of an innovative methodological approach to understand core trial processes, namely recruitment and intervention delivery, using a behavioural science approach to develop strategies designed to mitigate trial process problems.
Original languageEnglish
Article number398
Number of pages16
Issue number1
Early online date12 May 2022
Publication statusPublished - 12 May 2022

Bibliographical note

We thank the UK-REBOA site staf for dedicating their time to be interviewed


  • Trial methodology
  • Behavioural science
  • Complex interventions
  • Process evaluations
  • Theoretical domains framework


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