Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat

M P Law, S Osman, R J Davenport, V J Cunningham, V W Pike, P G Camici

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.
Original languageEnglish
Pages (from-to)417-24
Number of pages8
JournalNuclear Medicine and Biology
Issue number5
Publication statusPublished - 1997


  • Animals
  • Carbon Radioisotopes
  • Desipramine
  • Dose-Response Relationship, Drug
  • Ephedrine
  • Male
  • Myocardium
  • Rats
  • Rats, Sprague-Dawley
  • Tissue Distribution


Dive into the research topics of 'Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine in the rat'. Together they form a unique fingerprint.

Cite this