C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease

Kazuya Tone; Mark H.T. Stappers; Janet A. Willment; Gordon D. Brown

doi:10.1002/eji.201847536

C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease

Kazuya Tone
, Mark H.T. Stappers
, Janet A. Willment^* (Corresponding Author)
, Gordon D. Brown^* (Corresponding Author)

^*Corresponding author for this work

University of Exeter

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

12 Downloads (Pure)

Abstract

C-type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin-1 cluster, comprising of seven receptors including MICL, CLEC-2, CLEC-12B, CLEC-9A, MelLec, Dectin-1 and LOX-1. Reflecting the larger CLR family, the Dectin-1 cluster of receptors has a broad range of ligands and functions, but importantly, are involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis and other autoimmune diseases. In this mini-review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin-1 cluster CLRs, focussing on their physiological roles and involvement in disease

Original language	English
Pages (from-to)	2127-2133
Number of pages	7
Journal	European Journal of Immunology
Volume	49
Issue number	12
Early online date	13 Nov 2019
DOIs	https://doi.org/10.1002/eji.201847536
Publication status	Published - Dec 2019

Bibliographical note

Acknowledgements: We apologise to our many colleagues whose valuable work we could not cite due to space constraints. Funding was provided by the Wellcome Trust (102705, 097377), the Medical Research Council Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). KT received a research fellowship from Jikei University School of Medicine.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

C-type lectin
Dectin-1
autoimmunity
immunity

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10.1002/eji.201847536Licence: CC BY

Tone_etal_EurJImm_C‐type_lectin_VOR
© 2019 The Authors. European Journal of Immunology published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Final published version, 383 KBLicence: CC BY

Cite this

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title = "C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease",

abstract = "C-type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin-1 cluster, comprising of seven receptors including MICL, CLEC-2, CLEC-12B, CLEC-9A, MelLec, Dectin-1 and LOX-1. Reflecting the larger CLR family, the Dectin-1 cluster of receptors has a broad range of ligands and functions, but importantly, are involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis and other autoimmune diseases. In this mini-review, we discuss the latest advancements in elucidating the function(s) of each of the Dectin-1 cluster CLRs, focussing on their physiological roles and involvement in disease",

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C-type lectin receptors of the Dectin-1 cluster: Physiological roles and involvement in disease

Abstract

Bibliographical note

UN SDGs

Keywords

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