C-type lectin receptors orchestrate antifungal immunity

Sarah E. Hardison; Gordon D. Brown

doi:10.1038/ni.2369

C-type lectin receptors orchestrate antifungal immunity

Sarah E. Hardison
, Gordon D. Brown^*

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

398 Citations (Scopus)

Abstract

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.

Original language	English
Pages (from-to)	817-822
Number of pages	6
Journal	Nature Immunology
Volume	13
Issue number	9
Early online date	21 Aug 2012
DOIs	https://doi.org/10.1038/ni.2369
Publication status	Published - 1 Sept 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/ni.2369

Cite this

@article{bc8747c6b20c4f968ede499b5716c3d8,

title = "C-type lectin receptors orchestrate antifungal immunity",

abstract = "Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.",

author = "Hardison, \{Sarah E.\} and Brown, \{Gordon D.\}",

year = "2012",

month = sep,

day = "1",

doi = "10.1038/ni.2369",

language = "English",

volume = "13",

pages = "817--822",

journal = "Nature Immunology",

publisher = "Nature Research",

number = "9",

}

TY - JOUR

T1 - C-type lectin receptors orchestrate antifungal immunity

AU - Hardison, Sarah E.

AU - Brown, Gordon D.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.

AB - Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.

UR - https://www.scopus.com/pages/publications/84865411904

U2 - 10.1038/ni.2369

DO - 10.1038/ni.2369

M3 - Article

C2 - 22910394

VL - 13

SP - 817

EP - 822

JO - Nature Immunology

JF - Nature Immunology

IS - 9

ER -

C-type lectin receptors orchestrate antifungal immunity

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this