C-type lectins in immunity and homeostasis

Gordon D Brown* (Corresponding Author), Janet A Willment, Lauren Whitehead

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

360 Citations (Scopus)
30 Downloads (Pure)


The C-type lectins comprise a superfamily of proteins that recognise a broad repertoire of ligands and that regulate a diverse range of physiological functions. Most research attention has focused on the ability of C-type lectins to function in innate and adaptive antimicrobial immune responses, but these proteins are increasingly being recognised to have a major role in autoimmune diseases and to contribute to many other aspects of multicellular existence. Defects in these molecules lead to developmental and physiological abnormalities, as well as altered susceptibility to infectious and non-infectious diseases. In this Review, we present an overview of the roles of C-type lectins in immunity and homeostasis, with an emphasis on the most exciting recent discoveries. 
Original languageEnglish
Pages (from-to)374-389
Number of pages16
JournalNature Reviews Immunology
Early online date26 Mar 2018
Publication statusPublished - 2018

Bibliographical note

The authors thank the Wellcome Trust, the UK Medical Research Council (MRC), the MRC Centre for Medical Mycology at the University of Aberdeen and Arthritis Research UK for financial support. The authors apologize to colleagues whose many valuable contributions could not be cited owing to space constraints.


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