Cellular and molecular aspects of gastric cancer

Malcolm G. Smith, Georgina Louise Hold, Eiichi Tahara, Emad Munir El-Omar

Research output: Contribution to journalLiterature review

220 Citations (Scopus)


Gastric cancer remains a global killer with a shifting burden from the developed to the developing world. The cancer develops along a multistage process that is defined by distinct histological and pathophysiological phases. Several genetic and epigenetic alterations mediate the transition from one stage to another and these include mutations in oncogenes, tumour suppressor genes and cell cycle and mismatch repair genes. The most significant advance in the fight against gastric caner came with the recognition of the role of Helicobacter pylori (H pylori) as the most important acquired aetiological agent for this cancer. Recent work has focussed on elucidating the complex host/microbial interactions that underlie the neoplastic process. There is now considerable insight into the pathogenesis of this cancer and the prospect of preventing and eradicating the disease has become a reality. Perhaps more importantly, the study of H pylori-induced gastric carcinogenesis offers a paradigm for understanding more complex human cancers. In this review, we examine the molecular and cellular events that underlie H pylori-induced gastric cancer. (c) 2006 The WJG Press. All rights reserved.

Original languageEnglish
Pages (from-to)2979-2990
Number of pages12
JournalWorld Journal of Gastroenterology
Issue number19
Publication statusPublished - 21 May 2006


  • gastric cancer
  • Helicobacter pylori
  • hostmicrobial interactions
  • inflammation
  • molecular mechanisms
  • host genetics
  • helicobacter pylori infection
  • NF-kappa-B
  • epidermal growth factor
  • human gastrointestinal carcinomas
  • telomerase reverse transcriptase
  • cytokine gene polymorphisms
  • microsatellite instability
  • epithelial cells
  • nitric oxide
  • stomach cancer


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