Changes in inflammatory mediators during orthotopic liver transplantation

M. C. Bellamy*, H. F. Galley, N. R. Webster

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Transplantation is associated with an inflammatory rejection response. Graft reperfusion causes typical haemodynamic and biochemical responses. In this study we have investigated the relationship between these haemodynamic responses and changes in circulating inflammatory mediators after graft reperfusion in 10 consecutive patients undergoing orthotopic liver transplantation. After reperfusion, systemic vascular resistance index decreased (P = 0.011) and cardiac index increased (P = 0.038). These characteristic haemodynamic changes of the reperfusion syndrome were accompanied by global increases in cytokine concentrations. Plasma concentrations of leukotrienes decreased, while thromboxane B2 and platelet activating factor remained increased throughout. Reperfusion-mediated changes in inflammatory mediators may account for the haemodynamic disturbance.

Original languageEnglish
Pages (from-to)338-341
Number of pages4
JournalBritish Journal of Anaesthesia
Issue number3
Publication statusPublished - 1 Jan 1997


  • Immune response
  • Liver, transplantation
  • Polypeptides, cytokines


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