Childhood obesity in relation to poor asthma control and exacerbations: A meta-analysis

Fariba Ahmadizar; Susanne J H Vijverberg; Hubertus G. M. Arets; Anthonius de Boer; Jason E Lang; Meyer Kattan; Colin Palmer; Somnath Mukhopadhyay; Steve Turner; Anke Hilse Maitland-van der Zee

doi:10.1183/13993003.00766-2016

Childhood obesity in relation to poor asthma control and exacerbations: A meta-analysis

Fariba Ahmadizar
, Susanne J H Vijverberg
, Hubertus G. M. Arets
, Anthonius de Boer
, Jason E Lang
, Meyer Kattan
, Colin Palmer
, Somnath Mukhopadhyay
, Steve Turner
, Anke Hilse Maitland-van der Zee

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

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Abstract

To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex.

A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed- or random-effects models.

In a meta-analysis of 46 070 asthmatic children and adolescents, obese children (body mass index ≥95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95% CI 1.03–1.34; I2: 54.7%). However, there was no statistically significant association between obesity and poor asthma control (n=4973, OR 1.23, 95% CI 0.99–1.53; I2: 0.0%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant.

In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk.

Original language	English
Pages (from-to)	1063-1073
Number of pages	11
Journal	European Respiratory Journal
Volume	48
Issue number	4
Early online date	30 Sept 2016
DOIs	https://doi.org/10.1183/13993003.00766-2016
Publication status	Published - 1 Oct 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

body mass index
overweight
children
asthma severity

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Cite this

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title = "Childhood obesity in relation to poor asthma control and exacerbations: A meta-analysis",

abstract = "To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex. A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed- or random-effects models. In a meta-analysis of 46 070 asthmatic children and adolescents, obese children (body mass index ≥95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95\% CI 1.03{\textendash}1.34; I2: 54.7\%). However, there was no statistically significant association between obesity and poor asthma control (n=4973, OR 1.23, 95\% CI 0.99{\textendash}1.53; I2: 0.0\%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant. In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk.",

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AU - de Boer, Anthonius

AU - Lang, Jason E

AU - Kattan, Meyer

AU - Palmer, Colin

AU - Mukhopadhyay, Somnath

AU - Turner, Steve

AU - Maitland-van der Zee, Anke Hilse

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AB - To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex. A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed- or random-effects models. In a meta-analysis of 46 070 asthmatic children and adolescents, obese children (body mass index ≥95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95% CI 1.03–1.34; I2: 54.7%). However, there was no statistically significant association between obesity and poor asthma control (n=4973, OR 1.23, 95% CI 0.99–1.53; I2: 0.0%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant. In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk.

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ER -

Childhood obesity in relation to poor asthma control and exacerbations: A meta-analysis

Abstract

UN SDGs

Keywords

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