Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba

Thomas Dzeha; Marcel Jaspars; Jioji Tabudravu

doi:10.4314/wiojms.v2i2.28436

Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba

Thomas Dzeha
, Marcel Jaspars^* (Corresponding Author)
, Jioji Tabudravu

^*Corresponding author for this work

Kenya Marine and Fisheries Research Institute

Research output: Contribution to journal › Article › peer-review

15 Downloads (Pure)

Abstract

The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.

Original language	English
Pages (from-to)	157-161
Number of pages	5
Journal	Western Indian Ocean Journal of Marine Science
Volume	2
Issue number	2
DOIs	https://doi.org/10.4314/wiojms.v2i2.28436
Publication status	Published - 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Keywords

clionasterol
macroalga
Halimeda macroloba
spectroscopy
bioprospecting
Kenya

Access to Document

10.4314/wiojms.v2i2.28436Licence: CC BY

Clionasterol
This work is licensed under a Creative Commons Attribution 3.0 License: http://creativecommons.org/licenses/by/3.0/
Final published version, 134 KBLicence: CC BY

Cite this

@article{fe53eb732973437ca05d11d60d8f04d9,

title = "Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba",

abstract = "The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20\% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.",

keywords = "clionasterol, macroalga, Halimeda macroloba, spectroscopy, bioprospecting, Kenya",

author = "Thomas Dzeha and Marcel Jaspars and Jioji Tabudravu",

year = "2003",

doi = "10.4314/wiojms.v2i2.28436",

language = "English",

volume = "2",

pages = "157--161",

journal = "Western Indian Ocean Journal of Marine Science",

issn = "0856-860X",

publisher = "Western Indian Ocean Marine Science Association",

number = "2",

}

TY - JOUR

T1 - Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba

AU - Dzeha, Thomas

AU - Jaspars, Marcel

AU - Tabudravu, Jioji

PY - 2003

Y1 - 2003

N2 - The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.

AB - The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.

KW - clionasterol

KW - macroalga

KW - Halimeda macroloba

KW - spectroscopy

KW - bioprospecting

KW - Kenya

U2 - 10.4314/wiojms.v2i2.28436

DO - 10.4314/wiojms.v2i2.28436

M3 - Article

SN - 0856-860X

VL - 2

SP - 157

EP - 161

JO - Western Indian Ocean Journal of Marine Science

JF - Western Indian Ocean Journal of Marine Science

IS - 2

ER -

Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba

Abstract

UN SDGs

Keywords

Access to Document

Fingerprint

Cite this