CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment: Therapeutic Advances in Respiratory Disease

Iris van Geer-Postmus; Marika T. Leving; Yoran H. Gerritsma; Esmé Baan; Lars Dijk; Evelien Harms; David Price; Gerian H. Prins; Jennifer K. Quint; Dermot Ryan; Philippe Salomé; Björn Ställberg; Nilouq Stoker; Janwillem H. Kocks

doi:10.1177/17534666251329192

CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment: Therapeutic Advances in Respiratory Disease

Iris van Geer-Postmus^* (Corresponding Author), Marika T. Leving, Yoran H. Gerritsma, Esmé Baan, Lars Dijk, Evelien Harms, David Price, Gerian H. Prins, Jennifer K. Quint, Dermot Ryan, Philippe Salomé, Björn Ställberg, Nilouq Stoker, Janwillem H. Kocks

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Prevention of lung attacks (LAs)/exacerbation is an important treatment goal in both asthma and chronic obstructive pulmonary disease (COPD). However, LAs are often not registered as such in medical records.Objectives: Development and evaluation of CodeX Asthma and COPD.Design: An electronic medical record-based algorithm to identify LAs in Dutch primary care patients with asthma or COPD was developed. The algorithms were evaluated in nine general practices in the Netherlands.Results: A total of 479 LAs (in 1164 patients) were identified with CodeX Asthma in the past year, of which only 16% were registered. CodeX COPD identified 321 LAs (in 242 patients) in the past 3?years, of which two were registered.Conclusion: CodeX algorithms are capable of identifying unrecorded LAs and high-risk/uncontrolled patients in an easy way. This offers primary care providers a simple solution to easily identify and closely manage high-risk patients with asthma or COPD by identifying LAs? frequency and potential under- or overtreatment.

Original language	English
Article number	17534666251329192
Number of pages	8
Journal	Therapeutic advances in respiratory disease
Volume	19
Early online date	30 Apr 2025
DOIs	https://doi.org/10.1177/17534666251329192
Publication status	E-pub ahead of print - 30 Apr 2025

Bibliographical note

We like to thank all participating general practitioners for using the CodeX Asthma or COPD report and sharing the data for research purposes. The following general practitioners participated: R.A. Riemersma, Appingedam; GP Practice Geulle (J. Muris), Geulle; Wind en van der Werf, Hoogezand; R. Boersma, Groningen; Veendokters, Barger-Compascuum; De Held (E. Visser), Groningen; T. Van Pelt, Meppel; de Noord-Ooster (D. Rezelman), Wagenborgen; het Kruispunt (A.F.M. Spreeuw), Vlaardingen.
Also, we like to thank Topicus for their collaboration and support in the development of the CodeX reports.

Keywords

algorithm
asthma
cardiopulmonary pathway
COPD
exacerbations
lung attacks
quality improvement
treatment optimalization

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Cite this

van Geer-Postmus, I., Leving, M. T., Gerritsma, Y. H., Baan, E., Dijk, L., Harms, E., Price, D., Prins, G. H., Quint, J. K., Ryan, D., Salomé, P., Ställberg, B., Stoker, N., & Kocks, J. H. (2025). CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment: Therapeutic Advances in Respiratory Disease. Therapeutic advances in respiratory disease, 19, Article 17534666251329192. Advance online publication. https://doi.org/10.1177/17534666251329192

CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment: Therapeutic Advances in Respiratory Disease. / van Geer-Postmus, Iris (Corresponding Author); Leving, Marika T.; Gerritsma, Yoran H. et al.
In: Therapeutic advances in respiratory disease, Vol. 19, 17534666251329192, 12.2025.

Research output: Contribution to journal › Article › peer-review

van Geer-Postmus, I, Leving, MT, Gerritsma, YH, Baan, E, Dijk, L, Harms, E, Price, D, Prins, GH, Quint, JK, Ryan, D, Salomé, P, Ställberg, B, Stoker, N & Kocks, JH 2025, 'CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment: Therapeutic Advances in Respiratory Disease', Therapeutic advances in respiratory disease, vol. 19, 17534666251329192. https://doi.org/10.1177/17534666251329192

van Geer-Postmus I, Leving MT, Gerritsma YH, Baan E, Dijk L, Harms E et al. CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment: Therapeutic Advances in Respiratory Disease. Therapeutic advances in respiratory disease. 2025 Dec;19:17534666251329192. Epub 2025 Apr 30. doi: 10.1177/17534666251329192

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title = "CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment: Therapeutic Advances in Respiratory Disease",

abstract = "Background: Prevention of lung attacks (LAs)/exacerbation is an important treatment goal in both asthma and chronic obstructive pulmonary disease (COPD). However, LAs are often not registered as such in medical records.Objectives: Development and evaluation of CodeX Asthma and COPD.Design: An electronic medical record-based algorithm to identify LAs in Dutch primary care patients with asthma or COPD was developed. The algorithms were evaluated in nine general practices in the Netherlands.Results: A total of 479 LAs (in 1164 patients) were identified with CodeX Asthma in the past year, of which only 16% were registered. CodeX COPD identified 321 LAs (in 242 patients) in the past 3?years, of which two were registered.Conclusion: CodeX algorithms are capable of identifying unrecorded LAs and high-risk/uncontrolled patients in an easy way. This offers primary care providers a simple solution to easily identify and closely manage high-risk patients with asthma or COPD by identifying LAs? frequency and potential under- or overtreatment.",

keywords = "algorithm, asthma, cardiopulmonary pathway, COPD, exacerbations, lung attacks, quality improvement, treatment optimalization",

author = "{van Geer-Postmus}, Iris and Leving, { Marika T.} and Gerritsma, { Yoran H.} and Esm{\'e} Baan and Lars Dijk and Evelien Harms and David Price and Prins, { Gerian H.} and Quint, { Jennifer K.} and Dermot Ryan and Philippe Salom{\'e} and Bj{\"o}rn St{\"a}llberg and Nilouq Stoker and Kocks, { Janwillem H.}",

note = "We like to thank all participating general practitioners for using the CodeX Asthma or COPD report and sharing the data for research purposes. The following general practitioners participated: R.A. Riemersma, Appingedam; GP Practice Geulle (J. Muris), Geulle; Wind en van der Werf, Hoogezand; R. Boersma, Groningen; Veendokters, Barger-Compascuum; De Held (E. Visser), Groningen; T. Van Pelt, Meppel; de Noord-Ooster (D. Rezelman), Wagenborgen; het Kruispunt (A.F.M. Spreeuw), Vlaardingen. Also, we like to thank Topicus for their collaboration and support in the development of the CodeX reports.",

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journal = "Therapeutic advances in respiratory disease",

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T1 - CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment

T2 - Therapeutic Advances in Respiratory Disease

AU - van Geer-Postmus, Iris

AU - Leving, Marika T.

AU - Gerritsma, Yoran H.

AU - Baan, Esmé

AU - Dijk, Lars

AU - Harms, Evelien

AU - Price, David

AU - Prins, Gerian H.

AU - Quint, Jennifer K.

AU - Ryan, Dermot

AU - Salomé, Philippe

AU - Ställberg, Björn

AU - Stoker, Nilouq

AU - Kocks, Janwillem H.

N1 - We like to thank all participating general practitioners for using the CodeX Asthma or COPD report and sharing the data for research purposes. The following general practitioners participated: R.A. Riemersma, Appingedam; GP Practice Geulle (J. Muris), Geulle; Wind en van der Werf, Hoogezand; R. Boersma, Groningen; Veendokters, Barger-Compascuum; De Held (E. Visser), Groningen; T. Van Pelt, Meppel; de Noord-Ooster (D. Rezelman), Wagenborgen; het Kruispunt (A.F.M. Spreeuw), Vlaardingen. Also, we like to thank Topicus for their collaboration and support in the development of the CodeX reports.

PY - 2025/4/30

Y1 - 2025/4/30

N2 - Background: Prevention of lung attacks (LAs)/exacerbation is an important treatment goal in both asthma and chronic obstructive pulmonary disease (COPD). However, LAs are often not registered as such in medical records.Objectives: Development and evaluation of CodeX Asthma and COPD.Design: An electronic medical record-based algorithm to identify LAs in Dutch primary care patients with asthma or COPD was developed. The algorithms were evaluated in nine general practices in the Netherlands.Results: A total of 479 LAs (in 1164 patients) were identified with CodeX Asthma in the past year, of which only 16% were registered. CodeX COPD identified 321 LAs (in 242 patients) in the past 3?years, of which two were registered.Conclusion: CodeX algorithms are capable of identifying unrecorded LAs and high-risk/uncontrolled patients in an easy way. This offers primary care providers a simple solution to easily identify and closely manage high-risk patients with asthma or COPD by identifying LAs? frequency and potential under- or overtreatment.

AB - Background: Prevention of lung attacks (LAs)/exacerbation is an important treatment goal in both asthma and chronic obstructive pulmonary disease (COPD). However, LAs are often not registered as such in medical records.Objectives: Development and evaluation of CodeX Asthma and COPD.Design: An electronic medical record-based algorithm to identify LAs in Dutch primary care patients with asthma or COPD was developed. The algorithms were evaluated in nine general practices in the Netherlands.Results: A total of 479 LAs (in 1164 patients) were identified with CodeX Asthma in the past year, of which only 16% were registered. CodeX COPD identified 321 LAs (in 242 patients) in the past 3?years, of which two were registered.Conclusion: CodeX algorithms are capable of identifying unrecorded LAs and high-risk/uncontrolled patients in an easy way. This offers primary care providers a simple solution to easily identify and closely manage high-risk patients with asthma or COPD by identifying LAs? frequency and potential under- or overtreatment.

KW - algorithm

KW - asthma

KW - cardiopulmonary pathway

KW - COPD

KW - exacerbations

KW - lung attacks

KW - quality improvement

KW - treatment optimalization

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DO - 10.1177/17534666251329192

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JO - Therapeutic advances in respiratory disease

JF - Therapeutic advances in respiratory disease

M1 - 17534666251329192

ER -

CodeX effectively identifies high-risk patients with asthma or COPD in Dutch primary care, supporting guideline-driven treatment: Therapeutic Advances in Respiratory Disease

Abstract

Bibliographical note

Keywords

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