Cofactor NAD(P)H Regeneration: How Selective Are the Reactions?

Joseph W.H. Burnett; Russell F. Howe; Xiaodong Wang

doi:10.1016/j.trechm.2020.03.002

Cofactor NAD(P)H Regeneration: How Selective Are the Reactions?

Joseph W.H. Burnett, Russell F. Howe, Xiaodong Wang^* (Corresponding Author)

^*Corresponding author for this work

Lancaster University

Research output: Contribution to journal › Short survey › peer-review

13 Citations (Scopus)

Abstract

The regeneration of NAD(P)H can be achieved via catalysis, but the unequivocal determination of the species involved has not yet been fully realized. The current analytical methods of reactant/product analysis based on UV-vis spectroscopy, enzymatic assays, NMR spectroscopy, and HPLC are critically examined here with suggestions for future development.

Original language	English
Pages (from-to)	488-492
Number of pages	5
Journal	Trends in Chemistry
Volume	2
Issue number	6
Early online date	20 May 2020
DOIs	https://doi.org/10.1016/j.trechm.2020.03.002
Publication status	Published - Jun 2020

Bibliographical note

Funding Information:
This line of research in the Wang Group has been developed with financial support from the Royal Society (ICA\R1\180317, IES\R3\170162, IE150611, and RG150001), the EPSRC UK Catalysis Hub (via Energy Theme), British Council Newton Fund , and the Carnegie Trust for the Universities of Scotland ( 70265 ). We thank Dr Tony Saba, Mr Jianwei Li, Dr Wilm Jones, Dr Panagiotis N. Kechagiopoulos, and Prof James A. Anderson for their contribution to these projects.

Keywords

analytical methods
cofactor regeneration
conversion
mass balance
selectivity

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title = "Cofactor NAD(P)H Regeneration: How Selective Are the Reactions?",

abstract = "The regeneration of NAD(P)H can be achieved via catalysis, but the unequivocal determination of the species involved has not yet been fully realized. The current analytical methods of reactant/product analysis based on UV-vis spectroscopy, enzymatic assays, NMR spectroscopy, and HPLC are critically examined here with suggestions for future development.",

keywords = "analytical methods, cofactor regeneration, conversion, mass balance, selectivity",

author = "Burnett, {Joseph W.H.} and Howe, {Russell F.} and Xiaodong Wang",

note = "Funding Information: This line of research in the Wang Group has been developed with financial support from the Royal Society (ICA\R1\180317, IES\R3\170162, IE150611, and RG150001), the EPSRC UK Catalysis Hub (via Energy Theme), British Council Newton Fund , and the Carnegie Trust for the Universities of Scotland ( 70265 ). We thank Dr Tony Saba, Mr Jianwei Li, Dr Wilm Jones, Dr Panagiotis N. Kechagiopoulos, and Prof James A. Anderson for their contribution to these projects.",

year = "2020",

month = jun,

doi = "10.1016/j.trechm.2020.03.002",

language = "English",

volume = "2",

pages = "488--492",

journal = "Trends in Chemistry",

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TY - JOUR

T1 - Cofactor NAD(P)H Regeneration

T2 - How Selective Are the Reactions?

AU - Burnett, Joseph W.H.

AU - Howe, Russell F.

AU - Wang, Xiaodong

N1 - Funding Information: This line of research in the Wang Group has been developed with financial support from the Royal Society (ICA\R1\180317, IES\R3\170162, IE150611, and RG150001), the EPSRC UK Catalysis Hub (via Energy Theme), British Council Newton Fund , and the Carnegie Trust for the Universities of Scotland ( 70265 ). We thank Dr Tony Saba, Mr Jianwei Li, Dr Wilm Jones, Dr Panagiotis N. Kechagiopoulos, and Prof James A. Anderson for their contribution to these projects.

PY - 2020/6

Y1 - 2020/6

N2 - The regeneration of NAD(P)H can be achieved via catalysis, but the unequivocal determination of the species involved has not yet been fully realized. The current analytical methods of reactant/product analysis based on UV-vis spectroscopy, enzymatic assays, NMR spectroscopy, and HPLC are critically examined here with suggestions for future development.

AB - The regeneration of NAD(P)H can be achieved via catalysis, but the unequivocal determination of the species involved has not yet been fully realized. The current analytical methods of reactant/product analysis based on UV-vis spectroscopy, enzymatic assays, NMR spectroscopy, and HPLC are critically examined here with suggestions for future development.

KW - analytical methods

KW - cofactor regeneration

KW - conversion

KW - mass balance

KW - selectivity

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U2 - 10.1016/j.trechm.2020.03.002

DO - 10.1016/j.trechm.2020.03.002

M3 - Short survey

AN - SCOPUS:85083303203

SN - 2589-5974

VL - 2

SP - 488

EP - 492

JO - Trends in Chemistry

JF - Trends in Chemistry

IS - 6

ER -

Cofactor NAD(P)H Regeneration: How Selective Are the Reactions?

Abstract

Bibliographical note

Keywords

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