Cofactor NAD(P)H Regeneration: How Selective Are the Reactions?

Joseph W.H. Burnett, Russell F. Howe, Xiaodong Wang* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

11 Citations (Scopus)


The regeneration of NAD(P)H can be achieved via catalysis, but the unequivocal determination of the species involved has not yet been fully realized. The current analytical methods of reactant/product analysis based on UV-vis spectroscopy, enzymatic assays, NMR spectroscopy, and HPLC are critically examined here with suggestions for future development.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalTrends in Chemistry
Issue number6
Early online date20 May 2020
Publication statusPublished - Jun 2020

Bibliographical note

Funding Information:
This line of research in the Wang Group has been developed with financial support from the Royal Society (ICA\R1\180317, IES\R3\170162, IE150611, and RG150001), the EPSRC UK Catalysis Hub (via Energy Theme), British Council Newton Fund , and the Carnegie Trust for the Universities of Scotland ( 70265 ). We thank Dr Tony Saba, Mr Jianwei Li, Dr Wilm Jones, Dr Panagiotis N. Kechagiopoulos, and Prof James A. Anderson for their contribution to these projects.


  • analytical methods
  • cofactor regeneration
  • conversion
  • mass balance
  • selectivity


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