Cognitive profile and determinants of poor cognition in people without dementia in Parkinson’s disease

Max Barnish, David J. Daley, Katherine H.O. Deane, Allan B. Clark, Richard J. Gray, Simon M. C. Horton, Zoe R. Butterfint, Phyo K. Myint* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Background: The Montreal Cognitive Assessment (MoCA) has been recommended as a cognitive screening tool for clinical practice and research in Parkinson’s disease (PD), yet no normative data have been published for MoCA in PD without dementia. Methods: We undertook a pooled secondary analysis of data from two studies (one cross-sectional design and one clinical trial) conducted in the East of England region. All participants were aged 18 years or over, met UK Brain Bank criteria for PD and did not have clinical dementia. Cognitive status was assessed using MoCA at baseline in both studies. The influences of age, gender, disease duration, medication load (LEDD) and mood (HADS) on cognition were examined using regression analysis. Results: Data from 101 people with PD without dementia were available (mean age 71 years, 66% men). Median (IQR) MoCA was 25(22, 27). Age was found as the only predictor of MoCA in this sample. People aged over 71 had poorer MoCA (Beta=0.6 (95%CI 0.44, 0.82)) and an increased odds of MoCA <26 (Beta=0.29 (95%CI 0.12, 0.70)) as well as poorer scores on several MoCA subdomains. Conclusion: We present the normative data for MoCA in people with PD without clinical dementia. Age appeared to be the only associated factor for lower level of cognition, suggestive of Mild cognitive impairment in PD (PD-MCI) in PD without clinical diagnosis of dementia.
Original languageEnglish
Article number1
Number of pages5
JournalMedical Journal of the Islamic Republic of Iran
Publication statusPublished - 4 Feb 2019

Bibliographical note

Funding to MB and DJD from University of East Anglia. Neurology and Older People Medicine departments at the Norfolk and Norwich University Hospital, steering committee, Rachel Atkinson – clinical advice.


  • neuropsychology
  • cognition disorders
  • Parkinson disease
  • geriatrics
  • Cognition disorders
  • Neuropsychology
  • Geriatrics


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