Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

Yongyong Shi; Zhiqiang Li; Qi Xu; Ti Wang; Tao Li; Jiawei Shen; Fengyu Zhang; Jianhua Chen; Guoquan Zhou; Weidong Ji; Baojie Li; Yifeng Xu; Dengtang Liu; Peng Wang; Ping Yang; Benxiu Liu; Wensheng Sun; Chunling Wan; Shengying Qin; Guang He; Stacy Steinberg; Sven Cichon; Thomas Werge; Engilbert Sigurdsson; Sarah Tosato; Aarno Palotie; Markus M. Nöthen; Marcella Rietschel; Roel A. Ophoff; David A. Collier; Dan Rujescu; David St Clair; Hreinn Stefansson; Kari Stefansson; Jue Ji; Qingzhong Wang; Wenjin Li; Linqing Zheng; Hairong Zhang; Guoyin Feng; Lin He

doi:10.1038/ng.980

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

Yongyong Shi^*
, Zhiqiang Li
, Qi Xu
, Ti Wang
, Tao Li
, Jiawei Shen
, Fengyu Zhang
, Jianhua Chen
, Guoquan Zhou
, Weidong Ji
, Baojie Li
, Yifeng Xu
, Dengtang Liu
, Peng Wang
, Ping Yang
, Benxiu Liu
, Wensheng Sun
, Chunling Wan
, Shengying Qin
, Guang He

Stacy Steinberg, Sven Cichon, Thomas Werge, Engilbert Sigurdsson, Sarah Tosato, Aarno Palotie, Markus M. Nöthen, Marcella Rietschel, Roel A. Ophoff, David A. Collier, Dan Rujescu, David St Clair, Hreinn Stefansson, Kari Stefansson, Jue Ji, Qingzhong Wang, Wenjin Li, Linqing Zheng, Hairong Zhang, Guoyin Feng, Lin He

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

209 Citations (Scopus)

Abstract

Schizophrenia is a severe mental disorder affecting ∼1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10 ^-10) and 1q24.2 (rs10489202, P = 9.50 × 10 ^-9). Our findings provide new insights into the pathogenesis of schizophrenia.

Original language	English
Pages (from-to)	1224-1227
Number of pages	4
Journal	Nature Genetics
Volume	43
DOIs	https://doi.org/10.1038/ng.980
Publication status	Published - 1 Dec 2011

Bibliographical note

We are deeply grateful to all the participants as well as to the doctors working on this project. The authors also thank the editors and anonymous reviewers for their valuable comments on the manuscript. This work was supported by grants from the 973 Program (2010CB529600, 2009AA022701, 2006AA02A407), the Natural Science Foundation of China (81130022, 81121001, 31000553), the Foundation for the Author of National Excellent Doctoral Dissertation of China (201026), the Program for New Century Excellent Talents in University (NCET-09-0550), the Shanghai Municipal Health Bureau program (2008095), the Shanghai Changning Health Bureau program (2008406002), the Shanghai Municipal Commission of Science and Technology Program (09DJ1400601), the National Key Technology R&D Program (2006BAI05A09) and the Shanghai Leading Academic Discipline Project (B205).

Funding

from the 973 Program (2010CB529600, 2009AA022701, 2006AA02A407), the Natural Science Foundation of China (81130022, 81121001, 31000553), the Foundation for the Author of National Excellent Doctoral Dissertation of China (201026), the Program for New Century Excellent Talents in University (NCET-09-0550), the Shanghai Municipal Health Bureau program (2008095), the Shanghai Changning Health Bureau program (2008406002), the Shanghai Municipal Commission of Science and Technology Program (09DJ1400601), the National Key Technology R&D Program (2006BAI05A09) and the Shanghai Leading Academic Discipline Project (B205).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Cite this

Shi, Y, Li, Z, Xu, Q, Wang, T, Li, T, Shen, J, Zhang, F, Chen, J, Zhou, G, Ji, W, Li, B, Xu, Y, Liu, D, Wang, P, Yang, P, Liu, B, Sun, W, Wan, C, Qin, S, He, G, Steinberg, S, Cichon, S, Werge, T, Sigurdsson, E, Tosato, S, Palotie, A, Nöthen, MM, Rietschel, M, Ophoff, RA, Collier, DA, Rujescu, D, St Clair, D, Stefansson, H, Stefansson, K, Ji, J, Wang, Q, Li, W, Zheng, L, Zhang, H, Feng, G & He, L 2011, 'Common variants on 8p12 and 1q24.2 confer risk of schizophrenia', Nature Genetics, vol. 43, pp. 1224-1227. https://doi.org/10.1038/ng.980

@article{6317d954a49a42bb874edffcc7b238a0,

title = "Common variants on 8p12 and 1q24.2 confer risk of schizophrenia",

abstract = "Schizophrenia is a severe mental disorder affecting ∼1\% of the world population, with heritability of up to 80\%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10 -10) and 1q24.2 (rs10489202, P = 9.50 × 10 -9). Our findings provide new insights into the pathogenesis of schizophrenia.",

author = "Yongyong Shi and Zhiqiang Li and Qi Xu and Ti Wang and Tao Li and Jiawei Shen and Fengyu Zhang and Jianhua Chen and Guoquan Zhou and Weidong Ji and Baojie Li and Yifeng Xu and Dengtang Liu and Peng Wang and Ping Yang and Benxiu Liu and Wensheng Sun and Chunling Wan and Shengying Qin and Guang He and Stacy Steinberg and Sven Cichon and Thomas Werge and Engilbert Sigurdsson and Sarah Tosato and Aarno Palotie and N{\"o}then, \{Markus M.\} and Marcella Rietschel and Ophoff, \{Roel A.\} and Collier, \{David A.\} and Dan Rujescu and \{St Clair\}, David and Hreinn Stefansson and Kari Stefansson and Jue Ji and Qingzhong Wang and Wenjin Li and Linqing Zheng and Hairong Zhang and Guoyin Feng and Lin He",

note = "We are deeply grateful to all the participants as well as to the doctors working on this project. The authors also thank the editors and anonymous reviewers for their valuable comments on the manuscript. This work was supported by grants from the 973 Program (2010CB529600, 2009AA022701, 2006AA02A407), the Natural Science Foundation of China (81130022, 81121001, 31000553), the Foundation for the Author of National Excellent Doctoral Dissertation of China (201026), the Program for New Century Excellent Talents in University (NCET-09-0550), the Shanghai Municipal Health Bureau program (2008095), the Shanghai Changning Health Bureau program (2008406002), the Shanghai Municipal Commission of Science and Technology Program (09DJ1400601), the National Key Technology R\&D Program (2006BAI05A09) and the Shanghai Leading Academic Discipline Project (B205). ",

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AU - Shi, Yongyong

AU - Li, Zhiqiang

AU - Xu, Qi

AU - Wang, Ti

AU - Li, Tao

AU - Shen, Jiawei

AU - Zhang, Fengyu

AU - Chen, Jianhua

AU - Zhou, Guoquan

AU - Ji, Weidong

AU - Li, Baojie

AU - Xu, Yifeng

AU - Liu, Dengtang

AU - Wang, Peng

AU - Yang, Ping

AU - Liu, Benxiu

AU - Sun, Wensheng

AU - Wan, Chunling

AU - Qin, Shengying

AU - He, Guang

AU - Steinberg, Stacy

AU - Cichon, Sven

AU - Werge, Thomas

AU - Sigurdsson, Engilbert

AU - Tosato, Sarah

AU - Palotie, Aarno

AU - Nöthen, Markus M.

AU - Rietschel, Marcella

AU - Ophoff, Roel A.

AU - Collier, David A.

AU - Rujescu, Dan

AU - St Clair, David

AU - Stefansson, Hreinn

AU - Stefansson, Kari

AU - Ji, Jue

AU - Wang, Qingzhong

AU - Li, Wenjin

AU - Zheng, Linqing

AU - Zhang, Hairong

AU - Feng, Guoyin

AU - He, Lin

N1 - We are deeply grateful to all the participants as well as to the doctors working on this project. The authors also thank the editors and anonymous reviewers for their valuable comments on the manuscript. This work was supported by grants from the 973 Program (2010CB529600, 2009AA022701, 2006AA02A407), the Natural Science Foundation of China (81130022, 81121001, 31000553), the Foundation for the Author of National Excellent Doctoral Dissertation of China (201026), the Program for New Century Excellent Talents in University (NCET-09-0550), the Shanghai Municipal Health Bureau program (2008095), the Shanghai Changning Health Bureau program (2008406002), the Shanghai Municipal Commission of Science and Technology Program (09DJ1400601), the National Key Technology R&D Program (2006BAI05A09) and the Shanghai Leading Academic Discipline Project (B205).

PY - 2011/12/1

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N2 - Schizophrenia is a severe mental disorder affecting ∼1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10 -10) and 1q24.2 (rs10489202, P = 9.50 × 10 -9). Our findings provide new insights into the pathogenesis of schizophrenia.

AB - Schizophrenia is a severe mental disorder affecting ∼1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10 -10) and 1q24.2 (rs10489202, P = 9.50 × 10 -9). Our findings provide new insights into the pathogenesis of schizophrenia.

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DO - 10.1038/ng.980

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Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

Abstract

Bibliographical note

Funding

UN SDGs

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