Abstract
Multi-locus sequence typing data for 217 Candida albicans isolates Cultured since 1990 from blood and vaginal samples in Japan, England/Wales and the USA were analysed for geographically related variations. While no significant differences were found between distributions of diploid sequence types (DSTs) in blood vs. vaginal isolates, (here were highly significant differences in the clade distributions of isolates from the three geographical sources. Clade 2 strains were predominantly isolates from England/Wales, while clade 3 strains came mainly from the USA. The isolates from Japan were highly prevalent among strains in clades 5-17, and provided the first example seen so far in C. albicans of an amino acid encoded by three separate codons. Within clade 1, the most commonly encountered clade for isolates from all three regions, 15 Japanese isolates and I English isolate formed a separate clonal cluster in eBURST analysis. A similarly well demarcated clonal cluster rich isolates from Japan was also round among the clade 4 strains. The data suggest C albicans undergoes localized evolution, but human movements and person-to-person spread considerably blur the boundaries of such evolution. (C) 2007 Elsevier GmbH. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 663-668 |
| Number of pages | 6 |
| Journal | International Journal of Medical Microbiology: IJMM |
| Volume | 298 |
| Issue number | 7-8 |
| Early online date | 31 Oct 2007 |
| DOIs | |
| Publication status | Published - Oct 2008 |
Keywords
- Candida albicans
- Japan
- MLST
- Strain typing
- Molecular epidemiology
- Blood-stream infections
- Population
- Surveillance
- Patterns
- Eburst