COX-2 in the neurodegenerative process of Parkinson's disease

Peter Teismann

doi:10.1002/biof.1035

COX-2 in the neurodegenerative process of Parkinson's disease

Peter Teismann

Medical Sciences

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Abstract

The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in the neurodegenerative processes of a variety of diseases. This review looks particular at the role of COX-2 in the pathogenesis of Parkinson's disease, involving the generation of PGs and the role of the two different parts of the cyclooxygenase-cyclooxygenase and peroxidase activity.

Original language	English
Pages (from-to)	395-397
Number of pages	3
Journal	BioFactors
Volume	38
Issue number	6
DOIs	https://doi.org/10.1002/biof.1035
Publication status	Published - 25 Jul 2012

Bibliographical note

The author thanks Mrs. Birgit Teismann for her help in the preparation of this manuscript. The author wishes also to acknowledge the support of the Wellcome Trust (WT080782MF) and the NHS Endowment fund (06-09). The author declares that he has no conflict of interest.

Keywords

cyclooxygenase 2
humans
nerve degeneration
Parkinson disease
prostaglandin-endoperoxide synthases
prostaglandins

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10.1002/biof.1035Licence: Other

Teismann-2012-BioFactors
Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms Published under the terms of the Creative Commons Attribution (CC BY) licence: http://creativecommons.org/licenses/by/4.0/
Final published version, 65 KBLicence: Other

Cite this

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abstract = "The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in the neurodegenerative processes of a variety of diseases. This review looks particular at the role of COX-2 in the pathogenesis of Parkinson's disease, involving the generation of PGs and the role of the two different parts of the cyclooxygenase-cyclooxygenase and peroxidase activity.",

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N2 - The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in the neurodegenerative processes of a variety of diseases. This review looks particular at the role of COX-2 in the pathogenesis of Parkinson's disease, involving the generation of PGs and the role of the two different parts of the cyclooxygenase-cyclooxygenase and peroxidase activity.

AB - The enzyme cyclooxygenase-2 (COX-2), responsible for the first committed step in the synthesis of several important mediators which are involved in both initiation and resolution of inflammation, and the subsequent generation of prostaglandins (PGs) upon activation has been shown to participate in the neurodegenerative processes of a variety of diseases. This review looks particular at the role of COX-2 in the pathogenesis of Parkinson's disease, involving the generation of PGs and the role of the two different parts of the cyclooxygenase-cyclooxygenase and peroxidase activity.

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KW - nerve degeneration

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KW - prostaglandin-endoperoxide synthases

KW - prostaglandins

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JO - BioFactors

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ER -

COX-2 in the neurodegenerative process of Parkinson's disease

Abstract

Bibliographical note

Keywords

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