Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

Marcell Wagner, Wael M. Abdel-Mageed, Rainer Ebel, Alan T. Bull, Michael Goodfellow, Hans-Peter Fiedler*, Marcel Jaspars

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

Original languageEnglish
Pages (from-to)416-420
Number of pages5
JournalJournal of Natural Products
Volume77
Issue number2
Early online date5 Feb 2014
DOIs
Publication statusPublished - 22 Feb 2014

Bibliographical note

ACKNOWLEDGMENTS
The authors are grateful to the Kaiko operation team and the crew of M.S. Yokosuka, JAMSTEC, Yokosuka, Japan, for collecting sediment samples. M.W. thanks the Jürgen-ManchotFoundation for a generous scholarship and Max-BuchnerForschungsstiftung for support of consumables. M.J. is the recipient of a BBSRC Research Development Fellowship. The authors thank Mr A. Kulik, University of Tübingen, Germany, for assistance in fermentation and HPLC-ESIMS analysis. The
authors are grateful to EPSRC National Mass Spectrometric Centre, University of Wales, Swansea, for mass spectrometric analysis.

Keywords

  • marine-sediments
  • challenger deep
  • streptomyces
  • actinobacteria
  • diversity

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