Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

Marcell Wagner, Wael M. Abdel-Mageed, Rainer Ebel, Alan T. Bull, Michael Goodfellow, Hans-Peter Fiedler*, Marcel Jaspars

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

Original languageEnglish
Pages (from-to)416-420
Number of pages5
JournalJournal of Natural Products
Issue number2
Early online date5 Feb 2014
Publication statusPublished - 22 Feb 2014

Bibliographical note

The authors are grateful to the Kaiko operation team and the crew of M.S. Yokosuka, JAMSTEC, Yokosuka, Japan, for collecting sediment samples. M.W. thanks the Jürgen-ManchotFoundation for a generous scholarship and Max-BuchnerForschungsstiftung for support of consumables. M.J. is the recipient of a BBSRC Research Development Fellowship. The authors thank Mr A. Kulik, University of Tübingen, Germany, for assistance in fermentation and HPLC-ESIMS analysis. The
authors are grateful to EPSRC National Mass Spectrometric Centre, University of Wales, Swansea, for mass spectrometric analysis.


  • marine-sediments
  • challenger deep
  • streptomyces
  • actinobacteria
  • diversity


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