Divalent metal-dependent regulation of hepcidin expression by MTF-1

Sara Balesaria; Bala Ramesh; Harry J. McArdle; Henry K. Bayele; Surjit K. S. Srai

doi:10.1016/j.febslet.2009.12.023

Divalent metal-dependent regulation of hepcidin expression by MTF-1

Sara Balesaria, Bala Ramesh, Harry J. McArdle, Henry K. Bayele, Surjit K. S. Srai

The Rowett Institute of Nutrition and Health

Dept Struct & Mol Biol

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1. Analysis of hepcidin mRNA and protein levels in hepatoma cells suggests that its expression may be regulated by divalent metal ions, with zinc inducing maximal effects on hepcidin levels. These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

Original language	English
Pages (from-to)	719-725
Number of pages	7
Journal	FEBS Letters
Volume	584
Issue number	4
DOIs	https://doi.org/10.1016/j.febslet.2009.12.023
Publication status	Published - 19 Feb 2010

Keywords

zinc
iron
hepcidin
MRE-binding transcription factor-1
metal response element
transcription factor MTF-1
metallothionein-IIA gene
intestinal caco-2 cells
zinc transporter
iron-metabolism
in-vitro
functional expression
responsive elements
binding activity
protein-binding

Access to Document

10.1016/j.febslet.2009.12.023

Cite this

@article{5507a8b519344153a4bcc4bf92c5580e,

title = "Divalent metal-dependent regulation of hepcidin expression by MTF-1",

abstract = "Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1. Analysis of hepcidin mRNA and protein levels in hepatoma cells suggests that its expression may be regulated by divalent metal ions, with zinc inducing maximal effects on hepcidin levels. These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.",

keywords = "zinc, iron, hepcidin, MRE-binding transcription factor-1, metal response element, transcription factor MTF-1, metallothionein-IIA gene, intestinal caco-2 cells, zinc transporter, iron-metabolism, in-vitro, functional expression, responsive elements, binding activity, protein-binding",

author = "Sara Balesaria and Bala Ramesh and McArdle, {Harry J.} and Bayele, {Henry K.} and Srai, {Surjit K. S.}",

year = "2010",

month = feb,

day = "19",

doi = "10.1016/j.febslet.2009.12.023",

language = "English",

volume = "584",

pages = "719--725",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Divalent metal-dependent regulation of hepcidin expression by MTF-1

AU - Balesaria, Sara

AU - Ramesh, Bala

AU - McArdle, Harry J.

AU - Bayele, Henry K.

AU - Srai, Surjit K. S.

PY - 2010/2/19

Y1 - 2010/2/19

N2 - Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1. Analysis of hepcidin mRNA and protein levels in hepatoma cells suggests that its expression may be regulated by divalent metal ions, with zinc inducing maximal effects on hepcidin levels. These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

AB - Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1. Analysis of hepcidin mRNA and protein levels in hepatoma cells suggests that its expression may be regulated by divalent metal ions, with zinc inducing maximal effects on hepcidin levels. These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

KW - zinc

KW - iron

KW - hepcidin

KW - MRE-binding transcription factor-1

KW - metal response element

KW - transcription factor MTF-1

KW - metallothionein-IIA gene

KW - intestinal caco-2 cells

KW - zinc transporter

KW - iron-metabolism

KW - in-vitro

KW - functional expression

KW - responsive elements

KW - binding activity

KW - protein-binding

U2 - 10.1016/j.febslet.2009.12.023

DO - 10.1016/j.febslet.2009.12.023

M3 - Article

SN - 0014-5793

VL - 584

SP - 719

EP - 725

JO - FEBS Letters

JF - FEBS Letters

IS - 4

ER -

Divalent metal-dependent regulation of hepcidin expression by MTF-1

Abstract

Keywords

Access to Document

Fingerprint

Cite this