Does adult ADHD interact with COMT val 158 met genotype to influence working memory performance?

Stefanie C Biehl* (Corresponding Author), Kathrin M Gschwendtner, Anne Guhn, Laura D Muller, Susanne Reichert, Julia Heupel, Andreas Reif, Jürgen Deckert, Martin J Herrmann, Christian P. Jacob

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
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Abstract

Both attention-deficit/hyperactivity disorder (ADHD) and catechol-O-methyltransferase (COMT) genotype have been linked to altered dopaminergic transmission and possible impairment in frontal lobe functioning. This study offers an investigation of a possible interaction between ADHD diagnosis and COMT genotype on measures of working memory and executive function. Thirty-five adults with ADHD, who were recruited from the ADHD outpatient clinic at the Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, and thirty-five matched healthy controls completed the Digit Span test and the Stroop Color Word Test. While there were no main effects of ADHD or COMT, the two factors interacted on both Digit Span subtests with the two groups’ met/met carriers showing significantly different performance on the Digit Span Forward subtest and the val/val carriers showing significantly different performance on the Digit Span Backward subtest. Findings provide preliminary support for a differential impact of COMT genotype on working memory measures in adult patients with ADHD compared to healthy controls.
Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalADHD Attention Deficit and Hyperactivity Disorders
Volume7
Issue number1
Early online date10 Jul 2014
DOIs
Publication statusPublished - Mar 2015

Bibliographical note

The authors wish to thank Inge Gröbner for coordinating the patient appointments. This work was supported by the Deutsche Forschungsgemeinschaft (DFG; Grants HE 4531/1-1 and RTG 1253/1).

Keywords

  • Adult ADHD
  • COMT genotype
  • working memory
  • executive function

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