Abstract
Background
Campylobacter infection is a major cause of bacterial gastrointestinal disease. Exposure to Campylobacter is known to produce an immune response in humans that can prevent future symptomatic infections. Further, studies of the general population have shown that seroprevalence to Campylobacter increases with age.
Methods
A large collection of serotyped Campylobacter isolates, obtained from human clinical faecal samples, were analysed by comparing the ratio of uncommon to common serotypes by different age groups, using χ2 tests.
Results
We have identified that older age groups, as well as having generally lower incidence, are significantly less likely to be infected by the more common serotypes.
Conclusion
These results are indicative of acquired immunity, however, further studies are needed to rule out the confounding effects of the variations in exposure pathways experienced by different age groups.
Campylobacter infection is a major cause of bacterial gastrointestinal disease. Exposure to Campylobacter is known to produce an immune response in humans that can prevent future symptomatic infections. Further, studies of the general population have shown that seroprevalence to Campylobacter increases with age.
Methods
A large collection of serotyped Campylobacter isolates, obtained from human clinical faecal samples, were analysed by comparing the ratio of uncommon to common serotypes by different age groups, using χ2 tests.
Results
We have identified that older age groups, as well as having generally lower incidence, are significantly less likely to be infected by the more common serotypes.
Conclusion
These results are indicative of acquired immunity, however, further studies are needed to rule out the confounding effects of the variations in exposure pathways experienced by different age groups.
| Original language | English |
|---|---|
| Article number | 66 |
| Number of pages | 5 |
| Journal | BMC Infectious Diseases |
| Volume | 5 |
| DOIs | |
| Publication status | Published - Aug 2005 |
Keywords
- antibody-responses
- infection
- antigens
- poultry
- risk
- coli
Access to Document
- Does age acquired immunity
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.