Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation

Keyphrases

• Malonate 100%
• D1 Receptor 100%
• Striatal Lesion 30%
• Lesion Volume 20%
• Hydroxyl Radical 20%
• 6-Hydroxydopamine-lesioned Rats 20%
• D2 Receptor 20%
• Dopamine D2 Receptor Agonist 20%
• Intrastriatal 20%
• 6-hydroxydopamine (6-OHDA) 10%
• Apomorphine 10%
• L-dopamine 10%
• N-methyltyramine 10%
• Dopamine Receptor 10%
• 2,3-dihydroxybenzoic Acid 10%
• SKF38393 10%
• Sulpiride 10%
• Dopamine Release 10%
• Nigrostriatal Pathway 10%
• Independent Generation 10%
• Succinate Dehydrogenase Inhibitor 10%
• GBR 12909 10%
• SCH23390 10%
• Lisuride 10%
• Cerebral Ischemia 10%
• Reserpine 10%
• Neuronal Death 10%
• Independent Pathway 10%
• Hypoxia 10%
• Nitric Oxide Radical 10%
• L-DOPA 10%
• VMAT2 10%
• Chemically Induced 10%
• Dopaminergic Neurotoxicity 10%
• Dopamine Uptake 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Malonate 100%
• Reactive Oxygen Metabolite 100%
• Hydroxyl Radical 20%
• Metirosine 10%
• DOPA 10%
• 2,3 Dihydroxybenzoic Acid 10%
• Reserpine 10%
• Sulpiride 10%
• Vesicular Monoamine Transporter 10%
• Succinate Dehydrogenase 10%
• Vanoxerine 10%
• Apomorphine 10%
• Microdialysis 10%
• Lisuride 10%
• Hypoxia 10%
• Excitotoxicity 10%
• Dopamine Receptor 10%

Neuroscience

• Malonate 100%
• D2-Receptor Agonists 20%
• D1-Receptor Agonists 20%
• Apomorphine 10%
• Excitotoxicity 10%
• Metirosine 10%
• Salicylate 10%
• Levosulpiride 10%
• Nigrostriatal Pathway 10%
• alpha methyl p tyrosine 10%
• Succinate Dehydrogenase 10%
• Fumarate Reductase 10%
• Reserpine 10%
• Sulpiride 10%
• Lisuride 10%
• Dopamine Release 10%
• Vesicular Monoamine Transporter 10%
• Dopamine Receptor 10%
• L-DOPA 10%
• Neuronal Cell Death 10%