Long-term over-consumption of calories undoubtedly represents a major driver of the current epidemic of overweight and obesity in developed countries and worldwide. At the opposite end of the spectrum, clinically significant states of inadequate calorie and nutrient consumption represent a major problem under specific circumstances such as in infection, cancer and following chemotherapy, as well as more generically in the elderly. The latter represents a growing cause for concern in Europe’s ageing population. The ambition to intervene at either end of the continuum of dietary intake and food choice, and in different age groups, requires that we improve our understanding of mechanisms of hunger and satiety, and this forms the rationale of the Full4Health project
The Full4Health project and its consortium of 19 labs from across Europe was constructed in response to an EU funding call in 2009 entitled ‘Neurological pathways regulating hunger/satiety and gut behaviour’. The resulting proposal (‘Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health’) was funded for 5 years and is now in its final months. The papers contained in this Special Issue of Peptides provide a glimpse into some of the research activity within the project, and thanks are due to Professor Karl-Heinz Herzig for inviting the consortium to contribute this Special Issue. It is hoped that readers who are interested in the content of this Special Issue will also visit the Full4Health website (www.full4health.eu) where a full list of original research papers and review articles emanating from the project can be found along with news briefs suitable for a more general audience.This Project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 266408 [Full4Health].