Effects of 6-hydroxymelatonin in human macrophage model of inflammasome activation in conditions mimicking sepsis

E. Musatti; N. Webster; H. Wilson; H. Galley

doi:10.1016/j.bja.2020.11.011

Effects of 6-hydroxymelatonin in human macrophage model of inflammasome activation in conditions mimicking sepsis

E. Musatti, N. Webster, H. Wilson, H. Galley

University of Aberdeen

Research output: Contribution to journal › Abstract › peer-review

Abstract

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated inflammatory host response to infection, characterised by cytokine release and oxidative stress. Caspase-1 activation and interleukin (IL-1β) release are classical indicators of inflammasome activation. 6-hydroxymelatonin (6OHM) is the main metabolite of melatonin and has potent antioxidant and anti-inflammatory activity. However little is known about its mode of action. The aim of this study was to investigate the effects of 6OHM in a human macrophage model of inflammasome activation under conditions mimicking sepsis

Original language	English
Pages (from-to)	E79-E80
Number of pages	2
Journal	British Journal of Anaesthesia
Volume	126
Issue number	2
Early online date	16 Jan 2021
DOIs	https://doi.org/10.1016/j.bja.2020.11.011
Publication status	Published - 19 Feb 2021
Event	Anaesthesia Research Conference - London Duration: 24 Nov 2020 → 24 Nov 2020

Bibliographical note

We acknowledge the support of the BJA/RCoA for a PhD studentship for Elena Musatti.

Access to Document

10.1016/j.bja.2020.11.011Licence: Unspecified

Cite this

@article{0f0a6124921d4820b5bcf56d88e04540,

title = "Effects of 6-hydroxymelatonin in human macrophage model of inflammasome activation in conditions mimicking sepsis",

abstract = "Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated inflammatory host response to infection, characterised by cytokine release and oxidative stress. Caspase-1 activation and interleukin (IL-1β) release are classical indicators of inflammasome activation. 6-hydroxymelatonin (6OHM) is the main metabolite of melatonin and has potent antioxidant and anti-inflammatory activity. However little is known about its mode of action. The aim of this study was to investigate the effects of 6OHM in a human macrophage model of inflammasome activation under conditions mimicking sepsis",

author = "E. Musatti and N. Webster and H. Wilson and H. Galley",

note = "We acknowledge the support of the BJA/RCoA for a PhD studentship for Elena Musatti.; Anaesthesia Research Conference ; Conference date: 24-11-2020 Through 24-11-2020",

year = "2021",

month = feb,

day = "19",

doi = "10.1016/j.bja.2020.11.011",

language = "English",

volume = "126",

pages = "E79--E80",

journal = "British Journal of Anaesthesia",

issn = "0007-0912",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Effects of 6-hydroxymelatonin in human macrophage model of inflammasome activation in conditions mimicking sepsis

AU - Musatti, E.

AU - Webster, N.

AU - Wilson, H.

AU - Galley, H.

N1 - We acknowledge the support of the BJA/RCoA for a PhD studentship for Elena Musatti.

PY - 2021/2/19

Y1 - 2021/2/19

N2 - Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated inflammatory host response to infection, characterised by cytokine release and oxidative stress. Caspase-1 activation and interleukin (IL-1β) release are classical indicators of inflammasome activation. 6-hydroxymelatonin (6OHM) is the main metabolite of melatonin and has potent antioxidant and anti-inflammatory activity. However little is known about its mode of action. The aim of this study was to investigate the effects of 6OHM in a human macrophage model of inflammasome activation under conditions mimicking sepsis

AB - Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated inflammatory host response to infection, characterised by cytokine release and oxidative stress. Caspase-1 activation and interleukin (IL-1β) release are classical indicators of inflammasome activation. 6-hydroxymelatonin (6OHM) is the main metabolite of melatonin and has potent antioxidant and anti-inflammatory activity. However little is known about its mode of action. The aim of this study was to investigate the effects of 6OHM in a human macrophage model of inflammasome activation under conditions mimicking sepsis

U2 - 10.1016/j.bja.2020.11.011

DO - 10.1016/j.bja.2020.11.011

M3 - Abstract

SN - 0007-0912

VL - 126

SP - E79-E80

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

IS - 2

T2 - Anaesthesia Research Conference

Y2 - 24 November 2020 through 24 November 2020

ER -

Effects of 6-hydroxymelatonin in human macrophage model of inflammasome activation in conditions mimicking sepsis

Abstract

Bibliographical note

Access to Document

Fingerprint

Cite this