Effects of combined training on quality of life in individuals with overweight-related type 2 diabetes: a pilot study of correlations with metabolic, inflammatory and thermogenic markers

Ivan Luiz Padilha Bonfante; Daniela Bastos Vieira; Marcelo Oliveira Batista; William Ciriaco Barbosa; Renata Garbellini Duft; Keryma Chaves da Silva Mateus; Ana Paula Boito Ramkrapes; Liliane Ribeiro Vasconcelos; Milena Monfort-Pires; Celso Darío Ramos; Licio Augusto Velloso; Mara Patricia Traina Chacon-Mikahil; Cláudia Regina Cavaglieri

doi:10.1080/07853890.2025.2530694

Effects of combined training on quality of life in individuals with overweight-related type 2 diabetes: a pilot study of correlations with metabolic, inflammatory and thermogenic markers

Ivan Luiz Padilha Bonfante^*
, Daniela Bastos Vieira
, Marcelo Oliveira Batista
, William Ciriaco Barbosa
, Renata Garbellini Duft
, Keryma Chaves da Silva Mateus
, Ana Paula Boito Ramkrapes
, Liliane Ribeiro Vasconcelos
, Milena Monfort-Pires
, Celso Darío Ramos
, Licio Augusto Velloso
, Mara Patricia Traina Chacon-Mikahil
, Cláudia Regina Cavaglieri

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

2 Downloads (Pure)

Abstract

Background: There is still a lack of information regarding the impact of training on the domains that constitute quality of life (QoL), and the relationship between QoL with hormonal, inflammatory and pro-thermogenic/anti-inflammatory components. Thus, the present work aimed to evaluate the effects of combined training (CT) on the QoL of individuals with overweight-related type 2 diabetes mellitus (T2DM) and to correlate (baseline values and CT-induced delta percentage changes (Δ%)) QoL variables with hormonal, inflammatory, and pro-thermogenic/anti-inflammatory components. Methods: Middle-aged individuals of both sexes and with overweight-related T2DM were assigned to either the control group (CONT group) or the combined training group (CTG). The CT consisted of strength training followed by aerobic training three times/week for 16 weeks. Pre- and post-intervention assessments included QoL perception, clinical variables, serum biochemical markers, and brown adipose tissue (BAT) activity. Results: The CTG showed improvement in the perception of general QoL (20.0%) and in the physical (12.7%) and social (10.1%) domains. Significant positive correlations were observed between QoL variables with interleukin- 4 (IL-4), IL-10, IL-13, IL-33, Fibroblast growth factor- 21 (FGF-21), bone morphogenetic protein- 4 (BMP4), irisin, and BAT activity, alongside negative correlations with IL-1, IL-2, IL-6, c reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and incretin hormones at baseline and/or in the Δ% changes induced by training. Conclusion: CT improves the perception of general QoL and the physical and social domains of individuals with overweight-related T2DM. Baseline and in the Δ% of CT change, QoL components are related with several clinical, hormonal, inflammatory, and pro-thermogenic/anti-inflammatory markers, besides BAT increased activity.

Original language	English
Article number	2530694
Number of pages	15
Journal	Annals of Medicine
Volume	57
Issue number	1
Early online date	16 Jul 2025
DOIs	https://doi.org/10.1080/07853890.2025.2530694
Publication status	E-pub ahead of print - 16 Jul 2025

Bibliographical note

Acknowledgments
The authors thank the participants; Obesity and Comorbidities Research Center – University of Campinas; Faculty of Physical Education – University of Campinas; Integrated Teaching, Research and Extension Laboratory – School of Physical Education – University of Campinas. Finally, we thank the funding agencies, cited mentioned below.

Data Availability Statement

The data that support the findings of this study may be made available from the corresponding author upon reasonable request, depending on confidentiality level of the requested data.

Funding

The study was supported by S\u00E3o Paulo Research Foundation (FAPESP)\u2013S\u00E3o Paulo/Brazil\u2013Regular Research Grants\u2013Process: 2016/08751-3; Coordination for the Improvement of Higher Education Personnel (CAPES)-Brazil\u2013Financing Code 001; National Council for Scientific and Technological Development (CNPQ)\u2013Brazil-Financing Code 307985/2022-9. The authors thank the participants; Obesity and Comorbidities Research Center\u2013University of Campinas; Faculty of Physical Education\u2013University of Campinas; Integrated Teaching, Research and Extension Laboratory\u2013School of Physical Education\u2013University of Campinas. Finally, we thank the funding agencies, cited mentioned below.

Funders	Funder number
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação de Amparo à Pesquisa do Estado de São Paulo	2016/08751-3

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Combined training
inflammation
metabolism
quality of life
thermogenesis
type 2 diabetes

Access to Document

10.1080/07853890.2025.2530694Licence: CC BY-NC

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© 2025 The Author(s). Published by informa UK limited, trading as Taylor & francis Group. This is an open Access article distributed under the terms of the creative commons Attribution-noncommercial license (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
Final published version, 1.55 MBLicence: CC BY-NC

Cite this

Bonfante, I. L. P., Vieira, D. B., Batista, M. O., Barbosa, W. C., Duft, R. G., Mateus, K. C. D. S., Ramkrapes, A. P. B., Vasconcelos, L. R., Monfort-Pires, M., Ramos, C. D., Velloso, L. A., Chacon-Mikahil, M. P. T., & Cavaglieri, C. R. (2025). Effects of combined training on quality of life in individuals with overweight-related type 2 diabetes: a pilot study of correlations with metabolic, inflammatory and thermogenic markers. Annals of Medicine, 57(1), Article 2530694. Advance online publication. https://doi.org/10.1080/07853890.2025.2530694

Effects of combined training on quality of life in individuals with overweight-related type 2 diabetes: a pilot study of correlations with metabolic, inflammatory and thermogenic markers. / Bonfante, Ivan Luiz Padilha; Vieira, Daniela Bastos; Batista, Marcelo Oliveira et al.
In: Annals of Medicine, Vol. 57, No. 1, 2530694, 16.07.2025.

Research output: Contribution to journal › Article › peer-review

Bonfante, ILP, Vieira, DB, Batista, MO, Barbosa, WC, Duft, RG, Mateus, KCDS, Ramkrapes, APB, Vasconcelos, LR, Monfort-Pires, M, Ramos, CD, Velloso, LA, Chacon-Mikahil, MPT & Cavaglieri, CR 2025, 'Effects of combined training on quality of life in individuals with overweight-related type 2 diabetes: a pilot study of correlations with metabolic, inflammatory and thermogenic markers', Annals of Medicine, vol. 57, no. 1, 2530694. https://doi.org/10.1080/07853890.2025.2530694

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abstract = "Background: There is still a lack of information regarding the impact of training on the domains that constitute quality of life (QoL), and the relationship between QoL with hormonal, inflammatory and pro-thermogenic/anti-inflammatory components. Thus, the present work aimed to evaluate the effects of combined training (CT) on the QoL of individuals with overweight-related type 2 diabetes mellitus (T2DM) and to correlate (baseline values and CT-induced delta percentage changes (Δ\%)) QoL variables with hormonal, inflammatory, and pro-thermogenic/anti-inflammatory components. Methods: Middle-aged individuals of both sexes and with overweight-related T2DM were assigned to either the control group (CONT group) or the combined training group (CTG). The CT consisted of strength training followed by aerobic training three times/week for 16 weeks. Pre- and post-intervention assessments included QoL perception, clinical variables, serum biochemical markers, and brown adipose tissue (BAT) activity. Results: The CTG showed improvement in the perception of general QoL (20.0\%) and in the physical (12.7\%) and social (10.1\%) domains. Significant positive correlations were observed between QoL variables with interleukin- 4 (IL-4), IL-10, IL-13, IL-33, Fibroblast growth factor- 21 (FGF-21), bone morphogenetic protein- 4 (BMP4), irisin, and BAT activity, alongside negative correlations with IL-1, IL-2, IL-6, c reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and incretin hormones at baseline and/or in the Δ\% changes induced by training. Conclusion: CT improves the perception of general QoL and the physical and social domains of individuals with overweight-related T2DM. Baseline and in the Δ\% of CT change, QoL components are related with several clinical, hormonal, inflammatory, and pro-thermogenic/anti-inflammatory markers, besides BAT increased activity.",

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author = "Bonfante, \{Ivan Luiz Padilha\} and Vieira, \{Daniela Bastos\} and Batista, \{Marcelo Oliveira\} and Barbosa, \{William Ciriaco\} and Duft, \{Renata Garbellini\} and Mateus, \{Keryma Chaves da Silva\} and Ramkrapes, \{Ana Paula Boito\} and Vasconcelos, \{Liliane Ribeiro\} and Milena Monfort-Pires and Ramos, \{Celso Dar{\'i}o\} and Velloso, \{Licio Augusto\} and Chacon-Mikahil, \{Mara Patricia Traina\} and Cavaglieri, \{Cl{\'a}udia Regina\}",

note = "Acknowledgments The authors thank the participants; Obesity and Comorbidities Research Center – University of Campinas; Faculty of Physical Education – University of Campinas; Integrated Teaching, Research and Extension Laboratory – School of Physical Education – University of Campinas. Finally, we thank the funding agencies, cited mentioned below.",

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doi = "10.1080/07853890.2025.2530694",

language = "English",

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T1 - Effects of combined training on quality of life in individuals with overweight-related type 2 diabetes

T2 - a pilot study of correlations with metabolic, inflammatory and thermogenic markers

AU - Bonfante, Ivan Luiz Padilha

AU - Vieira, Daniela Bastos

AU - Batista, Marcelo Oliveira

AU - Barbosa, William Ciriaco

AU - Duft, Renata Garbellini

AU - Mateus, Keryma Chaves da Silva

AU - Ramkrapes, Ana Paula Boito

AU - Vasconcelos, Liliane Ribeiro

AU - Monfort-Pires, Milena

AU - Ramos, Celso Darío

AU - Velloso, Licio Augusto

AU - Chacon-Mikahil, Mara Patricia Traina

AU - Cavaglieri, Cláudia Regina

N1 - Acknowledgments The authors thank the participants; Obesity and Comorbidities Research Center – University of Campinas; Faculty of Physical Education – University of Campinas; Integrated Teaching, Research and Extension Laboratory – School of Physical Education – University of Campinas. Finally, we thank the funding agencies, cited mentioned below.

PY - 2025/7/16

Y1 - 2025/7/16

N2 - Background: There is still a lack of information regarding the impact of training on the domains that constitute quality of life (QoL), and the relationship between QoL with hormonal, inflammatory and pro-thermogenic/anti-inflammatory components. Thus, the present work aimed to evaluate the effects of combined training (CT) on the QoL of individuals with overweight-related type 2 diabetes mellitus (T2DM) and to correlate (baseline values and CT-induced delta percentage changes (Δ%)) QoL variables with hormonal, inflammatory, and pro-thermogenic/anti-inflammatory components. Methods: Middle-aged individuals of both sexes and with overweight-related T2DM were assigned to either the control group (CONT group) or the combined training group (CTG). The CT consisted of strength training followed by aerobic training three times/week for 16 weeks. Pre- and post-intervention assessments included QoL perception, clinical variables, serum biochemical markers, and brown adipose tissue (BAT) activity. Results: The CTG showed improvement in the perception of general QoL (20.0%) and in the physical (12.7%) and social (10.1%) domains. Significant positive correlations were observed between QoL variables with interleukin- 4 (IL-4), IL-10, IL-13, IL-33, Fibroblast growth factor- 21 (FGF-21), bone morphogenetic protein- 4 (BMP4), irisin, and BAT activity, alongside negative correlations with IL-1, IL-2, IL-6, c reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and incretin hormones at baseline and/or in the Δ% changes induced by training. Conclusion: CT improves the perception of general QoL and the physical and social domains of individuals with overweight-related T2DM. Baseline and in the Δ% of CT change, QoL components are related with several clinical, hormonal, inflammatory, and pro-thermogenic/anti-inflammatory markers, besides BAT increased activity.

AB - Background: There is still a lack of information regarding the impact of training on the domains that constitute quality of life (QoL), and the relationship between QoL with hormonal, inflammatory and pro-thermogenic/anti-inflammatory components. Thus, the present work aimed to evaluate the effects of combined training (CT) on the QoL of individuals with overweight-related type 2 diabetes mellitus (T2DM) and to correlate (baseline values and CT-induced delta percentage changes (Δ%)) QoL variables with hormonal, inflammatory, and pro-thermogenic/anti-inflammatory components. Methods: Middle-aged individuals of both sexes and with overweight-related T2DM were assigned to either the control group (CONT group) or the combined training group (CTG). The CT consisted of strength training followed by aerobic training three times/week for 16 weeks. Pre- and post-intervention assessments included QoL perception, clinical variables, serum biochemical markers, and brown adipose tissue (BAT) activity. Results: The CTG showed improvement in the perception of general QoL (20.0%) and in the physical (12.7%) and social (10.1%) domains. Significant positive correlations were observed between QoL variables with interleukin- 4 (IL-4), IL-10, IL-13, IL-33, Fibroblast growth factor- 21 (FGF-21), bone morphogenetic protein- 4 (BMP4), irisin, and BAT activity, alongside negative correlations with IL-1, IL-2, IL-6, c reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and incretin hormones at baseline and/or in the Δ% changes induced by training. Conclusion: CT improves the perception of general QoL and the physical and social domains of individuals with overweight-related T2DM. Baseline and in the Δ% of CT change, QoL components are related with several clinical, hormonal, inflammatory, and pro-thermogenic/anti-inflammatory markers, besides BAT increased activity.

KW - Combined training

KW - inflammation

KW - metabolism

KW - quality of life

KW - thermogenesis

KW - type 2 diabetes

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ER -

Effects of combined training on quality of life in individuals with overweight-related type 2 diabetes: a pilot study of correlations with metabolic, inflammatory and thermogenic markers

Abstract

Bibliographical note

Data Availability Statement

Funding

UN SDGs

Keywords

Access to Document

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Cite this