Essential metals at the host-pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens

Aaron Crawford, Duncan Wilson*

*Corresponding author for this work

Research output: Contribution to journalBook/Film/Article reviewpeer-review

92 Citations (Scopus)
11 Downloads (Pure)

Abstract

The ability of pathogenic microorganisms to assimilate sufficient nutrients for growth within their hosts is a fundamental requirement for pathogenicity. However, certain trace nutrients, including iron, zinc and manganese, are actively withheld from invading pathogens in a process called nutritional immunity. Therefore, successful pathogenic species must have evolved specialized mechanisms in order to adapt to the nutritionally restrictive environment of the host and cause disease. In this review, we discuss recent advances which have been made in our understanding of fungal iron and zinc acquisition strategies and nutritional immunity against fungal infections, and explore the mechanisms of micronutrient uptake by human pathogenic fungi.

Original languageEnglish
Article numberfov071
Pages (from-to)1-11
Number of pages11
JournalFEMS Yeast Research
Volume15
Issue number7
DOIs
Publication statusPublished - Nov 2015

Bibliographical note

AC and DW are supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).

Keywords

  • zinc
  • iron
  • host-pathogen interactions
  • fungal pathogenicity

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