Abstract
The ability of pathogenic microorganisms to assimilate sufficient nutrients for growth within their hosts is a fundamental requirement for pathogenicity. However, certain trace nutrients, including iron, zinc and manganese, are actively withheld from invading pathogens in a process called nutritional immunity. Therefore, successful pathogenic species must have evolved specialized mechanisms in order to adapt to the nutritionally restrictive environment of the host and cause disease. In this review, we discuss recent advances which have been made in our understanding of fungal iron and zinc acquisition strategies and nutritional immunity against fungal infections, and explore the mechanisms of micronutrient uptake by human pathogenic fungi.
| Original language | English |
|---|---|
| Article number | fov071 |
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | FEMS Yeast Research |
| Volume | 15 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Nov 2015 |
Bibliographical note
AC and DW are supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).Funding
AC and DW are supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).
Keywords
- zinc
- iron
- host-pathogen interactions
- fungal pathogenicity
Access to Document
- Essential metals at the host–pathogen interface: nutritional immunity and micronutrient assimilation by human fungal pathogens
© FEMS 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.