Evidence for altered placental blood flow and vascularity in compromised pregnancies

L P Reynolds, Joel Caton, D A Redmer, A T Grazul-Bilska, K A Vonnahme, P P Borowicz, J S Luther, Jacqueline Wallace, G Wu, T E Spencer

Research output: Contribution to journalLiterature reviewpeer-review

287 Citations (Scopus)


The placenta is the organ that transports nutrients, respiratory gases, and wastes between the maternal and fetal systems. Consequently, placental blood flow and vascular development are essential components of normal placental function and are critical to fetal growth and development. Normal fetal growth and development are important to ensure optimum health of offspring throughout their subsequent life course. In numerous sheep models of compromised pregnancy, in which fetal or placental growth, or both, are impaired, utero-placental blood flows are reduced. In the models that have been evaluated, placental vascular development also is altered. Recent studies found that treatments designed to increase placental blood flow can 'rescue' fetal growth that was reduced due to low maternal dietary intake. Placental blood flow and vascular development are thus potential therapeutic targets in compromised pregnancies.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalThe Journal of Physiology
Issue number1
Publication statusPublished - 1 Apr 2006


  • human fetoplacental vasculogenesis
  • endothelial vasodilator production
  • intrauterine growth restriction
  • sildenafil citrate viagra
  • velocity wave-forms
  • fetal-growth
  • systemic arteries
  • nitric-oxide
  • maternal undernutrition
  • nutrient restriction


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