Abstract
Peritumoural cytotoxic lymphocytic infiltrates in colorectal carcinoma may attack tumour cells by expressing Fas ligand and inducing tumour cell apoptosis. However, tumours may mount a 'counter-attack' by down regulating their Fas pathway and expressing Fas ligand themselves to induce apoptosis of lymphocytes. This study used immunohistochemistry to demonstrate the presence of CD8(+) lymphocytes and Fas ligand. The score of CD8(+) peritumoural lymphocytes was negatively correlated with the Fas ligand score of the tumour. The results provide evidence for the Fas 'counter-attack' theory, but further work would be required to determine if this is a significant factor in the tumour-host interaction.
Original language | English |
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Pages (from-to) | 45-47 |
Number of pages | 3 |
Journal | Oncology Reports |
Volume | 7 |
Publication status | Published - 2000 |
Keywords
- colorectal cancer
- CD95
- tumour infiltrating lymphocytes
- TUMOR-INFILTRATING LYMPHOCYTES
- RECTAL-CANCER
- CELLS
- COLON
- APOPTOSIS
- CLASSIFICATION
- MECHANISMS
- CARCINOMA
- ANTIBODY
- LIGAND