Factors associated with age of onset and type of menopause in a cohort of UK women

Alida J. Pokoradi; Lisa Iversen; Philip C. Hannaford

doi:10.1016/j.ajog.2011.02.059

Factors associated with age of onset and type of menopause in a cohort of UK women

Alida J. Pokoradi
, Lisa Iversen
, Philip C. Hannaford

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

OBJECTIVE: We sought to describe the pattern of age at menopause and factors associated with type of menopause.
STUDY DESIGN: This was a prospective cohort study of 5113 postmenopausal health survey respondents in the Royal College of General Practitioners’ Oral Contraception Study. Logistic regression was used to evaluate associations between sociodemographics, lifestyle, and medical history and menopause type.
RESULTS: Median age at natural menopause (n=3650) was 49.0 years (interquartile range, 45.0 –51.0), and at surgical menopause (n=1463) was 42.4 years (38.0 – 46.4). Early natural menopause was associated with smoking, ever-use of oral contraception, sterilization, and history of endometriosis (all increased odds ratios) and ever-use of hormone replacement therapy (decreased). Surgical menopause was associated with manual social class, sterilization, and having a history of endometriosis, menorrhagia, or painful menstruation (all increased), and ever-use of hormone replacement therapy (decreased).
CONCLUSION: Age at natural menopause was younger in this cohort than in other studies. More associations were found for surgical menopause than early natural menopause.

Original language	English
Pages (from-to)	34.e1-34.e13
Number of pages	13
Journal	American Journal of Obstetrics and Gynecology
Volume	205
Issue number	1
Early online date	27 Feb 2011
DOIs	https://doi.org/10.1016/j.ajog.2011.02.059
Publication status	Published - Jul 2011

Bibliographical note

Acknowledgments
We thank Prof Amanda Lee and the medical statistics team at the University of Aberdeen and Data Management Services for their expert advice. We also thank the 1400 recruiting GPs and the thousands of women who participated in the health survey.

Keywords

age
menopause
natural menopause
onset
risk factors
surgical menopause

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title = "Factors associated with age of onset and type of menopause in a cohort of UK women",

abstract = "OBJECTIVE: We sought to describe the pattern of age at menopause and factors associated with type of menopause. STUDY DESIGN: This was a prospective cohort study of 5113 postmenopausal health survey respondents in the Royal College of General Practitioners{\textquoteright} Oral Contraception Study. Logistic regression was used to evaluate associations between sociodemographics, lifestyle, and medical history and menopause type. RESULTS: Median age at natural menopause (n=3650) was 49.0 years (interquartile range, 45.0 {\textendash}51.0), and at surgical menopause (n=1463) was 42.4 years (38.0 {\textendash} 46.4). Early natural menopause was associated with smoking, ever-use of oral contraception, sterilization, and history of endometriosis (all increased odds ratios) and ever-use of hormone replacement therapy (decreased). Surgical menopause was associated with manual social class, sterilization, and having a history of endometriosis, menorrhagia, or painful menstruation (all increased), and ever-use of hormone replacement therapy (decreased). CONCLUSION: Age at natural menopause was younger in this cohort than in other studies. More associations were found for surgical menopause than early natural menopause.",

keywords = "age, menopause, natural menopause, onset, risk factors, surgical menopause",

author = "Pokoradi, \{Alida J.\} and Lisa Iversen and Hannaford, \{Philip C.\}",

note = "Acknowledgments We thank Prof Amanda Lee and the medical statistics team at the University of Aberdeen and Data Management Services for their expert advice. We also thank the 1400 recruiting GPs and the thousands of women who participated in the health survey.",

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AU - Pokoradi, Alida J.

AU - Iversen, Lisa

AU - Hannaford, Philip C.

N1 - Acknowledgments We thank Prof Amanda Lee and the medical statistics team at the University of Aberdeen and Data Management Services for their expert advice. We also thank the 1400 recruiting GPs and the thousands of women who participated in the health survey.

PY - 2011/7

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N2 - OBJECTIVE: We sought to describe the pattern of age at menopause and factors associated with type of menopause. STUDY DESIGN: This was a prospective cohort study of 5113 postmenopausal health survey respondents in the Royal College of General Practitioners’ Oral Contraception Study. Logistic regression was used to evaluate associations between sociodemographics, lifestyle, and medical history and menopause type. RESULTS: Median age at natural menopause (n=3650) was 49.0 years (interquartile range, 45.0 –51.0), and at surgical menopause (n=1463) was 42.4 years (38.0 – 46.4). Early natural menopause was associated with smoking, ever-use of oral contraception, sterilization, and history of endometriosis (all increased odds ratios) and ever-use of hormone replacement therapy (decreased). Surgical menopause was associated with manual social class, sterilization, and having a history of endometriosis, menorrhagia, or painful menstruation (all increased), and ever-use of hormone replacement therapy (decreased). CONCLUSION: Age at natural menopause was younger in this cohort than in other studies. More associations were found for surgical menopause than early natural menopause.

AB - OBJECTIVE: We sought to describe the pattern of age at menopause and factors associated with type of menopause. STUDY DESIGN: This was a prospective cohort study of 5113 postmenopausal health survey respondents in the Royal College of General Practitioners’ Oral Contraception Study. Logistic regression was used to evaluate associations between sociodemographics, lifestyle, and medical history and menopause type. RESULTS: Median age at natural menopause (n=3650) was 49.0 years (interquartile range, 45.0 –51.0), and at surgical menopause (n=1463) was 42.4 years (38.0 – 46.4). Early natural menopause was associated with smoking, ever-use of oral contraception, sterilization, and history of endometriosis (all increased odds ratios) and ever-use of hormone replacement therapy (decreased). Surgical menopause was associated with manual social class, sterilization, and having a history of endometriosis, menorrhagia, or painful menstruation (all increased), and ever-use of hormone replacement therapy (decreased). CONCLUSION: Age at natural menopause was younger in this cohort than in other studies. More associations were found for surgical menopause than early natural menopause.

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KW - risk factors

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DO - 10.1016/j.ajog.2011.02.059

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JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

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ER -

Factors associated with age of onset and type of menopause in a cohort of UK women

Abstract

Bibliographical note

Keywords

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