FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease

Bettina Platt; Andrew Welch; Gernot Riedel

doi:10.1042/BST0390874

FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease

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Abstract

The lack of reliable translational procedures applicable to both patients and experimental models are a major obstacle for the advancement of basic research as well as for the development of therapeutics. This is particularly relevant to neurodegenerative disorders such as AD (Alzheimer's disease), where the predictive validity of animal models and procedures applied preclinically have met with little success. Two approaches available for human diagnostics are currently experiencing major advancements in preclinical research: in vivo imaging using MRI (magnetic resonance imaging) or PET (positron-emission tomography) and recordings of brain electrical activity via surface EEG (electroencephalogram). The present paper reviews the results obtained so far in rodent AD models, and summarizes advantages and disadvantages of such procedures.

Original language	English
Pages (from-to)	874-880
Number of pages	7
Journal	Biochemical Society Transactions
Volume	39
Issue number	4
DOIs	https://doi.org/10.1042/BST0390874
Publication status	Published - Aug 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alzheimer's disease (AD)
Imaging
Positron-emission tomography (PET)
Power spectrum
Quantitative electroencephalogram
Sleep

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10.1042/BST0390874

FDG PET imaging
Platt, B, Welch, A & Riedel, G 2011, 'FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease', Biochemical Society Transactions, vol 39, no. 4, pp. 874-880. The final version of record is available at http://www.biochemsoctrans.org/bst/default.htm
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Cite this

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abstract = "The lack of reliable translational procedures applicable to both patients and experimental models are a major obstacle for the advancement of basic research as well as for the development of therapeutics. This is particularly relevant to neurodegenerative disorders such as AD (Alzheimer's disease), where the predictive validity of animal models and procedures applied preclinically have met with little success. Two approaches available for human diagnostics are currently experiencing major advancements in preclinical research: in vivo imaging using MRI (magnetic resonance imaging) or PET (positron-emission tomography) and recordings of brain electrical activity via surface EEG (electroencephalogram). The present paper reviews the results obtained so far in rodent AD models, and summarizes advantages and disadvantages of such procedures. ",

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KW - Alzheimer's disease (AD)

KW - Imaging

KW - Positron-emission tomography (PET)

KW - Power spectrum

KW - Quantitative electroencephalogram

KW - Sleep

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JO - Biochemical Society Transactions

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FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease

Abstract

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Keywords

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