Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya

Hai Deng, David O’Hagan (Corresponding Author), Christoph Schaffrath

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)


This review outlines the recent developments in uncovering the enzymes and intermediates involved in fluorometabolite biosynthesis in the bacterium Streptomyces cattleya. A particular emphasis is placed on the purification and characterisation of the fluorinase, the C–F bond forming enzyme which initiates the biosynthesis. Nature has hardly developed a biochemistry around fluorine, yet fluorinated organics are important commercial entities, therefore a biotransformation from inorganic to organic fluorine is novel and of contemporary interest.

Original languageEnglish
Pages (from-to)773-784
Number of pages12
JournalNatural Product Reports
Issue number6
Publication statusPublished - 2004


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