Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection

Michaela Lucas; Stephan Gadola; Ute Meier; Neil Thomas Young; Gillian Harcourt; Anastasios Karadimitris; Nikki Coumi; Dave Brown; Geoff Dusheiko; Vincenzo Cerundolo; Paul Klenerman

doi:10.1128/JVI.77.3.2251-2257.2003

Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection

Michaela Lucas, Stephan Gadola, Ute Meier, Neil Thomas Young, Gillian Harcourt, Anastasios Karadimitris, Nikki Coumi, Dave Brown, Geoff Dusheiko, Vincenzo Cerundolo, Paul Klenerman

Research output: Contribution to journal › Article › peer-review

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Abstract

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.

Original language	English
Pages (from-to)	2251-2257
Number of pages	7
Journal	Journal of Virology
Volume	77
Issue number	3
DOIs	https://doi.org/10.1128/JVI.77.3.2251-2257.2003
Publication status	Published - 1 Feb 2003

Keywords

Antigens, CD
Antigens, CD3
Antigens, CD56
Antigens, Differentiation, T-Lymphocyte
Hepatitis C
Humans
Immunophenotyping
Killer Cells, Natural
Lymphocyte Activation
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocyte Subsets

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/JVI.77.3.2251-2257.2003

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Lucas, M., Gadola, S., Meier, U., Young, N. T., Harcourt, G., Karadimitris, A., Coumi, N., Brown, D., Dusheiko, G., Cerundolo, V., & Klenerman, P. (2003). Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection. Journal of Virology, 77(3), 2251-2257. https://doi.org/10.1128/JVI.77.3.2251-2257.2003

Lucas, M, Gadola, S, Meier, U, Young, NT, Harcourt, G, Karadimitris, A, Coumi, N, Brown, D, Dusheiko, G, Cerundolo, V & Klenerman, P 2003, 'Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection', Journal of Virology, vol. 77, no. 3, pp. 2251-2257. https://doi.org/10.1128/JVI.77.3.2251-2257.2003

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abstract = "Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.",

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author = "Michaela Lucas and Stephan Gadola and Ute Meier and Young, {Neil Thomas} and Gillian Harcourt and Anastasios Karadimitris and Nikki Coumi and Dave Brown and Geoff Dusheiko and Vincenzo Cerundolo and Paul Klenerman",

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AU - Lucas, Michaela

AU - Gadola, Stephan

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AU - Young, Neil Thomas

AU - Harcourt, Gillian

AU - Karadimitris, Anastasios

AU - Coumi, Nikki

AU - Brown, Dave

AU - Dusheiko, Geoff

AU - Cerundolo, Vincenzo

AU - Klenerman, Paul

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KW - Antigens, CD

KW - Antigens, CD3

KW - Antigens, CD56

KW - Antigens, Differentiation, T-Lymphocyte

KW - Hepatitis C

KW - Humans

KW - Immunophenotyping

KW - Killer Cells, Natural

KW - Lymphocyte Activation

KW - Receptors, Antigen, T-Cell, alpha-beta

KW - T-Lymphocyte Subsets

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DO - 10.1128/JVI.77.3.2251-2257.2003

M3 - Article

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SN - 0022-538X

VL - 77

SP - 2251

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JO - Journal of Virology

JF - Journal of Virology

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ER -

Frequency and phenotype of circulating V alpha 24/V beta 11 double-positive natural killer T cells during hepatitis C virus infection

Abstract

Keywords

UN SDGs

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