Fungal cell wall: An underexploited target for antifungal therapies

Chibuike Ibe* (Corresponding Author), Carol Munro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)
11 Downloads (Pure)

Abstract

The cell wall of the major fungal pathogen Candida albicans consists of an outer layer that is made up of highly mannosylated proteins. The proteins are attached to the inner layer of the cell wall and appear perpendicular to the cell surface forming a fibrillar protein coat (Fig.1A). The polysaccharide rich inner layer is mainly made up of β-1,6- and β-1,3-glucans and chitin while β-1,3-glucans and chitin are the structural polysaccharides in the cell wall.
Original languageEnglish
Article numbere1009470
Number of pages7
JournalPLoS Pathogens
Volume17
Issue number4
DOIs
Publication statusPublished - 22 Apr 2021

Bibliographical note

Funding: The authors would like to acknowledge support from the University of Aberdeen and Abia State University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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