Abstract
Echinocandins are the most recent introduction to the antifungal armamentarium and target the synthesis of ß-(1,3)-glucan, the major structural polysaccharide of the fungal cell wall. Mechanisms have been identified that reduce the efficacy of the echinocandins: mutations of the Fks subunit of the target enzyme complex or a compensatory increase in the production of chitin, the second structural cell wall polysaccharide.
| Original language | English |
|---|---|
| Article number | 66 |
| Number of pages | 3 |
| Journal | F1000 Biology Reports |
| Volume | 2 |
| DOIs | |
| Publication status | Published - 8 Sept 2010 |